Diffusion of steroids in porous sol-gel glass: Application in slow drug delivery

被引：0
|
作者：
L. Sieminska
M. Ferguson
T. W. Zerda
E. Couch
机构：
[1] Slaska Akademia Medyczna,Department of Pathophysiology
[2] Texas Christian University,Physics Department
[3] Texas Christian University,Biology Department
来源：
Journal of Sol-Gel Science and Technology | 1997年 / 8卷
关键词：
diffusion; steroids; molecular motion; porous glass;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Samples of porous sol-gel glass, after being stabilized at 750°C, were impregnated with progesterone, estradiol, estrone, and hydrocortisone. Diffusion coefficients for those steroids inside the pores filled with pure ethanol, ethanol-water mixture or physiological solution were determined. It is shown that permeability is favored for steroids having fewer hydroxyl and carbonyl groups. Solvents that readily dissolve steroids increase the diffusion rate and thus the amount of delivered material. The flow of steroids in small pores is less restricted than in larger pores.
引用
收藏
页码：1105 / 1109
页数：4
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