Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

被引：0
作者：
Jiazhang Qiu
Michael J. Sheedlo
Kaiwen Yu
Yunhao Tan
Ernesto S. Nakayasu
Chittaranjan Das
Xiaoyun Liu
Zhao-Qing Luo
机构：
[1] Purdue Institute for Inflammation,Immunology and Infectious Disease and Department of Biological Sciences
[2] Purdue University,Department of Chemistry
[3] Purdue University,Biological Science Division
[4] Institute of Analytical Chemistry and Synthetic and Functional Biomolecules Center,undefined
[5] College of Chemistry and Molecular Engineering,undefined
[6] Peking University,undefined
[7] Pacific Northwest National Laboratory,undefined
[8] Present address: Division of Gastroenterology,undefined
[9] Boston Children’s Hospital,undefined
[10] Harvard Medical School,undefined
[11] Boston,undefined
[12] Massachusetts 02115,undefined
[13] USA.,undefined
来源：
Nature | 2016年 / 533卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An unprecedented mechanism of ubiquitination that is independent of E1 and E2 enzymes, instead relying on activation of ubiquitin by ADP-ribosylation, and which is mediated by members of the SidE effector family encoded by the bacterial pathogen Legionella pneumophila, establishes that ubiquitination can be carried out by a single enzyme.
引用
收藏
页码：120 / 124
页数：4
相关论文
共 96 条
  • [1] Komander D(2012)The ubiquitin code Annu. Rev. Biochem. 81 203-229
  • [2] Rape M(2014)Ubiquitin in the immune system EMBO Rep. 15 28-45
  • [3] Zinngrebe J(2015)Diversity of bacterial manipulation of the host ubiquitin pathways Cell. Microbiol. 17 26-34
  • [4] Montinaro A(2010)Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family Science 329 1215-1218
  • [5] Peltzer N(2013)Cell biology of infection by Microbes Infect. 15 157-167
  • [6] Walczak H(2004)Multiple substrates of the Proc. Natl Acad. Sci. USA 101 841-846
  • [7] Zhou Y(2011) Dot/Icm system identified by interbacterial protein transfer Cell. Microbiol. 13 227-245
  • [8] Zhu Y(2013)The E Block motif is associated with Proc. Natl Acad. Sci. USA 110 E707-E715
  • [9] Cui J(2011) translocated substrates PLoS Pathog. 7 e1001289-1076
  • [10] Xu L(2012)Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal Science 338 1072-992
12345678910