Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling

被引：0
作者：
Anaël Chazeau
Grégory Giannone
机构：
[1] University of Bordeaux,Interdisciplinary Institute for Neuroscience
[2] UMR 5297,Interdisciplinary Institute for Neuroscience
[3] CNRS,Cell Biology, Faculty of Science
[4] UMR 5297,undefined
[5] Utrecht University,undefined
来源：
Cellular and Molecular Life Sciences | 2016年 / 73卷
关键词：
Dendritic spines; Actin cytoskeleton; Actin binding proteins; PSD; CAMKII; Synaptic plasticity; Super-resolution microscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the central nervous system, most excitatory post-synapses are small subcellular structures called dendritic spines. Their structure and morphological remodeling are tightly coupled to changes in synaptic transmission. The F-actin cytoskeleton is the main driving force of dendritic spine remodeling and sustains synaptic plasticity. It is therefore essential to understand how changes in synaptic transmission can regulate the organization and dynamics of actin binding proteins (ABPs). In this review, we will provide a detailed description of the organization and dynamics of F-actin and ABPs in dendritic spines and will discuss the current models explaining how the actin cytoskeleton sustains both structural and functional synaptic plasticity.
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页码：3053 / 3073
页数：20
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