Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling

被引：0
作者：
Anaël Chazeau
Grégory Giannone
机构：
[1] University of Bordeaux,Interdisciplinary Institute for Neuroscience
[2] UMR 5297,Interdisciplinary Institute for Neuroscience
[3] CNRS,Cell Biology, Faculty of Science
[4] UMR 5297,undefined
[5] Utrecht University,undefined
来源：
Cellular and Molecular Life Sciences | 2016年 / 73卷
关键词：
Dendritic spines; Actin cytoskeleton; Actin binding proteins; PSD; CAMKII; Synaptic plasticity; Super-resolution microscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the central nervous system, most excitatory post-synapses are small subcellular structures called dendritic spines. Their structure and morphological remodeling are tightly coupled to changes in synaptic transmission. The F-actin cytoskeleton is the main driving force of dendritic spine remodeling and sustains synaptic plasticity. It is therefore essential to understand how changes in synaptic transmission can regulate the organization and dynamics of actin binding proteins (ABPs). In this review, we will provide a detailed description of the organization and dynamics of F-actin and ABPs in dendritic spines and will discuss the current models explaining how the actin cytoskeleton sustains both structural and functional synaptic plasticity.
引用
收藏
页码：3053 / 3073
页数：20
相关论文
共 1616 条
  • [1] Ramón y Cajal S S(1888)Estructura de los centros nerviosos de las aves Rev Trim Histol Norm Pat 1 1-10
  • [2] Yuste R(2015)The discovery of dendritic spines by Cajal Front Neuroanat 9 1-6
  • [3] Ramón y Cajal S(1891)Significación fisiológica de las expansiones protoplásmicas y nerviosas de la sustancia gris Rev Cienc Med Barcelona 22 23-468
  • [4] Ramón y Cajal S(1894)La fine structure des centres nerveux. The croonian lecture Proc R Soc Lond B 55 443-1593
  • [5] Gray EG(1959)Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex Nature 183 1592-433
  • [6] Gray EG(1959)Axo-somatic and axo-dendritic synapses of the cerebral cortex J Anat 93 420-598
  • [7] Guillery RW(2000)Early electron microscopic observations of synaptic structures in the cerebral cortex: a view of the contributions made by George Gray (1924–1999) Trends Neurosci 23 594-12756
  • [8] Kandel ER(2009)The biology of memory: a forty-year perspective J Neurosci 29 12748-12716
  • [9] Squire LR(2009)Memory and brain systems: 1969–2009 J Neurosci 29 12711-352
  • [10] Nabavi S(2014)Engineering a memory with LTD and LTP Nature 511 348-338
12345678910