The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship Between Microglia and Alzheimer’s Disease: A Novel Marker for a Promising Pathway to Explore

被引：0
作者：
Cristina Gussago
M. Casati
E. Ferri
B. Arosio
机构：
[1] Università degli Studi di Milano,Department of Medical Sciences and Community Health
[2] Ospedale Maggiore Policlinico,Geriatric Unit, Fondazione IRCCS Ca’ Granda
来源：
The Journal of Frailty & Aging | 2019年 / 8卷
关键词：
Alzheimer’s disease; microglia; aging; Triggering Receptor Expressed on Myeloid cells-2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alzheimer’s disease (AD) is a common neurodegenerative disorder, strongly related with age. It has been reported that genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2), a cell-surface receptor expressed in microglial cells, greatly increase the risk of AD, thus suggesting an involvement of the microglia in the AD pathogenesis. The aim of this report is to provide an overview of the TREM2 and of its possible implication in the pathogenesis of AD.
引用
收藏
页码：54 / 56
页数：2
相关论文
共 50 条
[11]   Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis [J].
Neumann, Harald ;
Takahashi, Kazuya .
JOURNAL OF NEUROIMMUNOLOGY, 2007, 184 (1-2) :92-99
[12]   Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke [J].
Kawabori, Masahito ;
Hokari, Masaaki ;
Zheng, Zhen ;
Kim, Jong Youl ;
Calosing, Cyrus ;
Hsieh, Christine L. ;
Nakamura, Mary C. ;
Yenari, Midori A. .
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT, 2013, 3 (04) :189-198
[13]   Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage [J].
Wunderlich, Patrick ;
Glebov, Konstantin ;
Kemmerling, Nadja ;
Tien, Nguyen T. ;
Neumann, Harald ;
Walter, Jochen .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (46) :33027-33036
[14]   Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma [J].
Peshoff, Mekenzie M. ;
Gupta, Pravesh ;
Oberai, Shivangi ;
Trivedi, Rakesh ;
Katayama, Hiroshi ;
Chakrapani, Prashanth ;
Dang, Minghao ;
Migliozzi, Simona ;
Gumin, Joy ;
Kadri, Divya B. ;
Lin, Jessica K. ;
Milam, Nancy K. ;
Maynard, Mark E. ;
Vaillant, Brian D. ;
Parker-Kerrigan, Brittany ;
Lang, Frederick F. ;
Huse, Jason T. ;
Iavarone, Antonio ;
Wang, Linghua ;
Clise-Dwyer, Karen ;
Bhat, Krishna P. .
NEURO-ONCOLOGY, 2024, 26 (05) :826-839
[15]   Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) [J].
Atagi, Yuka ;
Liu, Chia-Chen ;
Painter, Meghan M. ;
Chen, Xiao-Fen ;
Verbeeck, Christophe ;
Zheng, Honghua ;
Li, Xia ;
Rademakers, Rosa ;
Kang, Silvia S. ;
Xu, Huaxi ;
Younkin, Steven ;
Das, Pritam ;
Fryer, John D. ;
Bu, Guojun .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (43) :26043-26050
[16]   The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum [J].
Shi, Xiaolei ;
Zhong, Xiaomei ;
Zhou, Huarong ;
Zhou, Nan ;
Hu, Yachun ;
Ning, Yuping .
FRONTIERS IN NEUROLOGY, 2022, 13
[17]   The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia [J].
Roussos, Panos ;
Katsel, Pavel ;
Fam, Peter ;
Tan, Weilun ;
Purohit, Dushyant P. ;
Haroutunian, Vahram .
ALZHEIMERS & DEMENTIA, 2015, 11 (10) :1163-1170
[18]   The Effect of Triggering Receptor Expressed by Myeloid Cells 2 Modified Bone Marrow Mesenchymal Stem Cells on Alzheimer's Disease -Mouse Model [J].
Yang, Yun ;
Wu, Xiaomu ;
Qu, Xinhui ;
Wang, Xinrong ;
Luo, Chaoqun ;
Li, Lingjuan ;
Zhang, Kunnan .
ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2019, 49 (01) :23-30
[19]   Microglia-Related Gene Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) Is Upregulated in the Substantia Nigra of Progressive Supranuclear Palsy [J].
Sanchez-Ruiz de Gordoa, Javier ;
Elena Erro, Maria ;
Vicuna-Urriza, Janire ;
Victoria Zelaya, Maria ;
Tellechea, Paula ;
Acha, Blanca ;
Zueco, Sara ;
Urdanoz-Casado, Amaya ;
Roldan, Miren ;
Blanco-Luquin, Idoia ;
Mendioroz, Maite .
MOVEMENT DISORDERS, 2020, 35 (05) :885-890
[20]   Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2) [J].
Li Zhong ;
Zongqi Wang ;
Daxin Wang ;
Zhe Wang ;
Yuka A. Martens ;
Linbei Wu ;
Ying Xu ;
Kai Wang ;
Jianguo Li ;
Ruizhi Huang ;
Dan Can ;
Huaxi Xu ;
Guojun Bu ;
Xiao-Fen Chen .
Molecular Neurodegeneration, 13
12345