The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship Between Microglia and Alzheimer’s Disease: A Novel Marker for a Promising Pathway to Explore

被引：0
|
作者：
Cristina Gussago
M. Casati
E. Ferri
B. Arosio
机构：
[1] Università degli Studi di Milano,Department of Medical Sciences and Community Health
[2] Ospedale Maggiore Policlinico,Geriatric Unit, Fondazione IRCCS Ca’ Granda
来源：
The Journal of Frailty & Aging | 2019年 / 8卷
关键词：
Alzheimer’s disease; microglia; aging; Triggering Receptor Expressed on Myeloid cells-2;
D O I：
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中图分类号：
学科分类号：
摘要：
Alzheimer’s disease (AD) is a common neurodegenerative disorder, strongly related with age. It has been reported that genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2), a cell-surface receptor expressed in microglial cells, greatly increase the risk of AD, thus suggesting an involvement of the microglia in the AD pathogenesis. The aim of this report is to provide an overview of the TREM2 and of its possible implication in the pathogenesis of AD.
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页码：54 / 56
页数：2
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