Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation

被引：61
作者：
Franchini M. [1 ]
Lippi G. [2 ]
Manzato F. [3 ]
机构：
[1] Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona
[2] Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Università di Verona, Verona
[3] Laboratorio di Analisi Chimico-Cliniche, Mantova
来源：
Thrombosis Journal | / 4卷 / 1期
关键词：
Severe Sepsis; Disseminate Intravascular Coagulation; Fresh Freeze Plasma; Disseminate Intravascular Coagulation; Thrombin Generation;
D O I：
10.1186/1477-9560-4-4
中图分类号：
学科分类号：
摘要：
Disseminated intravascular coagulation (DIC) is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular formation of fibrin, and diffuse hemorrhages, due to the consumption of platelets and coagulation factors. Systemic activation of coagulation may occur in a variety of disorders, including sepsis, severe infections, malignancies, obstetric or vascular disorders, and severe toxic or immunological reactions. In this review, we briefly report the present knowledge about the pathophysiology and diagnosis of DIC. Particular attention is also given to the current standard and experimental therapies of overt DIC. © 2006 Franchini et al; licensee BioMed Central Ltd.
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