Impact of Airborne Particle Size, Acoustic Airflow and Breathing Pattern on Delivery of Nebulized Antibiotic into the Maxillary Sinuses Using a Realistic Human Nasal Replica

被引:0
作者
Lara Leclerc
Jérémie Pourchez
Gérald Aubert
Sandrine Leguellec
Laurent Vecellio
Michèle Cottier
Marc Durand
机构
[1] Université Jean Monnet,Laboratoire Interdisciplinaire d’étude des Nanoparticules Aérosolisées (LINA – EA 4624), Faculté de Médecine Jacques Lisfranc
[2] CIS-EMSE,Ecole Nationale Supérieure des Mines
[3] LINA EA 4624,Antibiology Department
[4] SFR IFRESIS,Centre d’Etudes des Pathologies Respiratoires INSERM U1100/EA 6305 Faculté de Médecine
[5] CHU Saint-Etienne,DTF Aerodrug, Faculté de Médecine
[6] Université François Rabelais,ENT Department
[7] Université François Rabelais,undefined
[8] Centre Hospitalier Emile Roux,undefined
来源
Pharmaceutical Research | 2014年 / 31卷
关键词
aerosol therapy; drug deposition; maxillary sinuses; nasal replica;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2335 / 2343
页数:8
相关论文
共 130 条
  • [1] Tarhan E(2005)Acoustic rhinometry in humans: accuracy of nasal passage area estimates, and ability to quantify paranasal sinus volume and ostium size J Appl Physiol 99 616-623
  • [2] Coskun M(2012)Nasal drug delivery—a review RGUHS J Pharm Sci 2 24-37
  • [3] Cakmak O(2013)Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review Drug Deliv Trans Res 3 42-62
  • [4] Çelik H(2002)Use of nebulized antibiotics for acute infections in chronic sinusitis Otolaryngol Head Neck Surg 127 558-568
  • [5] Cankurtaran M(2011)Deposition of aerosols delivered by nasal route with jet and mesh nebulizers Int J Pharm 407 87-94
  • [6] Deshpande T(2008)A prospective controlled trial of pulsed nasal nebulizer in maximally dissected cadavers Am J Rhinol 22 390-394
  • [7] Masareddy R(2011)Impact of acoustic airflow nebulization on intrasinus drug deposition of a human plastinated nasal cast: new insights into the mechanisms involved Int J Pharm 421 63-71
  • [8] Patil A(2008)Ventilation and drug delivery to the paranasal sinuses: studies in a nasal cast using pulsating airflow Rhinology 46 213-220
  • [9] Djupesland PG(2010)Assessment of nasal spray deposition pattern in a silicone human nose model using a color-based method Pharm Res 27 30-36
  • [10] Vaughan WC(2000)Detailed flow patterns in the nasal cavity J Appl Physiol Bethesda Md 1985 89 323-337