Effects of helium-neon laser irradiation and local anesthetics on potassium channels in pond snail neurons

被引：13

作者：

Ignatov Yu.D. ^{[1
]}

Vislobokov A.I. ^{[1
]}

Vlasov T.D. ^{[1
]}

Kolpakova M.É. ^{[1
]}

Mel'nikov K.N. ^{[1
]}

Petrishchev I.N. ^{[1
]}

机构：

[1] Academician I. P. Pavlov St. Petersburg State Medical University, Ministry of Health of the Russian Federation, 197022 St. Petersburg

来源：

Neuroscience and Behavioral Physiology | 2005年 / 35卷 / 8期

关键词：

Bupivacaine; Helium-neon laser; Neurons; Potassium ion currents;

D O I：

10.1007/s11055-005-0137-7

中图分类号：

学科分类号：

摘要：

Intracellular dialysis and membrane voltage clamping were used to show that He-Ne laser irradiation of a pond snail neuron at a dose of 0.7·10-4 J (power density 1.5·102 W/ m2) increases the amplitude of the potential-dependent slow potassium current, while a dose of 0.7·10-3 J decreases this current. Bupivacaine suppresses the potassium current. Combined application of laser irradiation at a dose of 0.7·10-3 J increased the blocking effect of 10 μM bupivacaine on the slow potassium current, while an irradiation dose of 0.7·10-4 J weakened the effect of bupivacaine. © 2005 Springer Science+Business Media, Inc.

引用

页码：871 / 875

页数：4

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