Differential effects of eprosartan and losartan at prejunctional angiotensin II receptors

被引：0

作者：

Serafim Guimarães

Helder Pinheiro

Paula Tavares

Ana Loio

Daniel Moura

机构：

[1] Institute of Pharmacology and Therapeutics,

[2] Faculty of Medicine,undefined

[3] Alameda Hernani Monteiro,undefined

[4] 4200-319 Porto,undefined

[5] Portugal,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 2001年 / 363卷

关键词：

Eprosartan Losartan PD123319 Angiotensin II receptors Rat ventricle Canine pulmonary artery;

D O I：

暂无

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学科分类号：

摘要：

A comparison was made of the influence of losartan and eprosartan on angiotensin II effects at pre- and postjunctional receptors of the canine pulmonary artery and at prejunctional receptors of the rat left ventricle. To study postjunctional contractile responses to angiotensin II, non-cumulative concentration-response curves were determined; to study prejunctional effects of angiotensin II, the tissues were preincubated with [3H]noradrenaline and then superfused and electrically stimulated (1 Hz, 2 ms, 50 mA, 5 min).

引用

页码：509 / 514

页数：5