DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus

被引：0
作者：
Xinna Wu
Xuqiang Zhou
Sanying Wang
Genxiang Mao
机构：
[1] Zhejiang University School of Medicine,Affiliated Zhejiang Hospital
[2] Zhejiang Hospital,Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics
[3] Zhejiang Chinese Medical University,College of Life Science
来源：
Virology Journal | / 20卷
关键词：
Human cytomegalovirus; DNA damage; Cellular senescence; Senescence-associated secretory phenotype; Cell cycle;
D O I：
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摘要：
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory cytokines. Human cytomegalovirus (HCMV) is a ubiquitous pathogen that plays an important role in the senescence process. It has been established that DDR is necessary for HCMV to replicate effectively. This paper reviews the relationship between DDR, cellular senescence, and HCMV, providing new sights for virus-induced senescence (VIS).
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