Chronic β-Citronellol Inhalation Rescues Parvalbumin Expression Loss in Prefrontal Cortex of Chronic Restraint Stress Mice

被引：0

作者：

Zhuang Q. ^{[1
]}

Zhuang S. ^{[1
]}

Gong Y. ^{[1
]}

Li S. ^{[1
]}

机构：

[1] Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai

来源：

Journal of Shanghai Jiaotong University (Science) | 2022年 / 27卷 / 04期

基金：

中国国家自然科学基金;

关键词：

A; chronic reastraint stress (CRS) model; depression; GABAergic neuron; parvalbumin; prefrontal cortex (PFC); Q; 189;

D O I：

10.1007/s12204-022-2455-0

中图分类号：

学科分类号：

摘要：

Considerable evidence has revealed that essential oils and their main constituents possess anti-depressant and anxiolytic properties. In the current study, we report the effect of β-citronellol, the main component of rose essential oil, on depressive-like and anxiety-like behaviors in chronic restraint stress (CRS) mice. We found that chronic inhalation of β-citronellol for 14 days could increase locomotor activity in the open field test, decrease the percentage of immobility duration in the forced swimming test, and increase open arms exploration in elevated plus-maze test in CRS mice. Western blot experiment shows that chronic β-citronellol inhalation rescues parvalbumin (PV) expression loss in the prefrontal cortex (PFC) of CRS mice. Correlation analysis reveals a strong relationship between the PV expression in PFC and the percentage of sucrose preference of the mice. These findings indicate the relationships between the PV gene expression of PFC and the effects of β-citronellol inhalation. © 2022, Shanghai Jiao Tong University.

引用

页码：512 / 520

页数：8

共 29 条

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