Preparation and physicochemical properties of Nicotinamide@AlOOH biocompatible composite based on sol-gel materials

被引：1

作者：

Vinogradov V.V. ^{[1
]}

Komova Y.M. ^{[2
]}

Vinogradov A.V. ^{[1
]}

Vinogradov V.V. ^{[1
]}

机构：

[1] G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, 153045

[2] Ivanovo State Chemicotechnological University, Ivanovo, 153000

[3] National Research University of Information Technologies, Mechanics and Optics, St. Petersburg, 197101

来源：

Nanotechnologies in Russia | 2014年 / 9卷 / 1-2期

关键词：

Sol-gels; -; Temperature; Corundum; Biocompatibility;

D O I：

10.1134/S1995078014010157

中图分类号：

学科分类号：

摘要：

This paper is devoted to studying the properties of the functional nanocomposite nicotinamide@boehmite. Nicotinamide is introduced directly into a sol of boehmite with the subsequent aging and drying. The results of obtaining high-purity boehmite sol prepared with the use of ultrasonic machining as a physical method of peptization are presented. The structure of the composite is studied with the help of a complex of methods: X-ray-phase analysis, IR-spectroscopy, electron microscopy, and the low-temperature adsorption-desorption of nitrogen. The release of nicotinamide is studied in a histidine buffer at pH = 7.4. Forty-eight percent of the introduced nicotinamide is released in the first 2 h with subsequent sharp retardation resulting in a complete release for a long time. © 2014 Pleiades Publishing, Ltd.

引用

页码：87 / 92

页数：5

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