Endoplasmic reticulum-associated degradation shown to regulate innate immunity

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Nature Cell Biology | 2023年 / 25卷
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The SEL1L–HRD1 endoplasmic reticulum-associated degradation pathway negatively regulates STING-mediated innate immunity by ubiquitinating and targeting STING for proteasomal degradation, thereby limiting its activation.
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页码：641 / 642
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