Neural mechanisms of target ranging in FM bats: physiological evidence from bats and frogs

被引:0
作者
Albert S. Feng
机构
[1] University of Illinois at Urbana-Champaign,Department of Molecular and Integrative Physiology, Beckman Institute
来源
Journal of Comparative Physiology A | 2011年 / 197卷
关键词
Frequency modulation; Paradoxical latency shift; Neural oscillation; Echolocation; Oscillation; Resonance; Inferior colliculus; Delay-tuned response;
D O I
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中图分类号
学科分类号
摘要
Echolocating bats assess target range by the delay in echo relative to the emitted sonar pulse. Earlier studies in FM bats showed that a population of neurons in auditory centers above the inferior colliculus (IC) is tuned to echo delay, with different neurons tuned to different echo delays. A building block for delay-tuned responses is paradoxical latency shift (PLS), featuring longer response latencies to more intense sounds. PLS is first created in the IC, where neurons exhibit unit-specific quantum increase in response latency with increasing sound level. Other IC neurons display oscillatory discharges whose period is unit-specific and level tolerant, indicating that this is attributable to cell’s intrinsic properties. High-threshold inhibition of oscillatory discharge produces PLS, indicating that oscillatory discharge is a building block for PLS. To investigate the cellular basis of oscillatory discharges, we performed whole-cell patch-clamp recordings from IC neurons in leopard frogs (which also exhibit oscillatory discharges and PLS). These recordings show that IC neurons are heterogeneous displaying diverse biophysical phenotypes; each phenotype (and cell) has its own membrane time constant, input resistance, and strengths of Ih, Ikir, Ikv—these intrinsic properties give rise to cell-specific resonance which can be observed through current and afferent stimulations.
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页码:595 / 603
页数:8
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