The thyroid gland and the process of aging; What is new?

被引：65
作者：
Gesing A. [1 ]
Lewiński A. [2 ,3 ]
Karbownik-Lewińska M. [1 ,2 ]
机构：
[1] Department of Oncological Endocrinology, Medical University of Lodz, Lodz, 90-752, Zeligowski St.
[2] Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz 93-338, Rzgowska St.
[3] Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, 93-338, Rzgowska St.
来源：
Thyroid Research | / 5卷 / 1期
关键词：
Aging; Longevity; Subclinical thyroid dysfunction; Thyroid cancer; Thyroid gland;
D O I：
10.1186/1756-6614-5-16
中图分类号：
学科分类号：
摘要：
The endocrine system and particular endocrine organs, including the thyroid, undergo important functional changes during aging. The prevalence of thyroid disorders increases with age and numerous morphological and physiological changes of the thyroid gland during the process of aging are well-known. It is to be stressed that the clinical course of thyroid diseases in the elderly differs essentially from that observed in younger individuals, because symptoms are more subtle and are often attributed to normal aging. Subclinical hypo- and hyperthyroidism, as well as thyroid neoplasms, require special attention in elderly subjects. Intriguingly, decreased thyroid function, as well as thyrotropin (TSH) levels - progressively shifting to higher values with age - may contribute to the increased lifespan.This short review focuses on recent findings concerning the alterations in thyroid function during aging, including these which may potentially lead to extended longevity, both in humans and animals. © 2012 Gesing et al.; licensee BioMed Central Ltd.
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  • [1] Lewinski A., Sewerynek E., Karbownik M., Aging processes and the thyroid gland, Aging and Age-Related Diseases: The Basics, pp. 131-172, (2006)
  • [2] Faggiano A., Del Prete M., Marciello F., Marotta V., Ramundo V., Colao A., Thyroid diseases in elderly, Minerva Endocrinol, 36, pp. 211-231, (2011)
  • [3] Papaleontiou M., Haymart M.R., Approach to and treatment of thyroid disorders in the elderly, Med Clin North Am, 96, pp. 297-310, (2012)
  • [4] Cooper D.S., Thyroid disease in the oldest old: The exception to the rule, Journal of the American Medical Association, 292, 21, pp. 2651-2654, (2004)
  • [5] Surks M.I., Ortiz E., Daniels G.H., Sawin C.T., Col N.F., Cobin R.H., Franklyn J.A., Hershman J.M., Burman K.D., Denke M.A., Gorman C., Cooper R.S., Weissman N.J., Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management, Journal of the American Medical Association, 291, 2, pp. 228-238, (2004)
  • [6] Ochs N., Auer R., Bauer D.C., Nanchen D., Gussekloo J., Cornuz J., Rodondi N., Meta-analysis: Subclinical thyroid dysfunction and the risk for coronary heart disease and mortality, Annals of Internal Medicine, 148, 11, pp. 832-845, (2008)
  • [7] Atzmon G., Barzilai N., Hollowell J.G., Surks M.I., Gabriely I., Extreme longevity is associated with increased serum thyrotropin, J Clin Endocrinol Metab, 94, pp. 1251-1254, (2009)
  • [8] Boucai L., Surks M.I., Reference limits of serum TSH and free T4 are significantly influenced by race and age in an urban outpatient medical practice, Clin Endocrinol, 70, pp. 788-793, (2009)
  • [9] Surks M.I., Boucai L., Age- and race-based serum thyrotropin reference limits, J Clin Endocrinol Metab, 95, pp. 496-502, (2010)
  • [10] Bremner A.P., Feddema P., Leedman P.J., Brown S.J., Beilby J.P., Lim E.M., Wilson S.G., O'Leary P.C., Walsh J.P., Age-related changes in thyroid function: A longitudinal study of a community-based cohort, J Clin Endocrinol Metab, 97, pp. 1554-1562, (2012)
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