Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

被引：0
作者：
De-Yang Shen
Ping-Chung Kuo
Shiow-Chyn Huang
Tsong-Long Hwang
Yu-Yi Chan
Po-Chuen Shieh
Nguyen Thi Ngan
Tran Dinh Thang
Tian-Shung Wu
机构：
[1] National Cheng Kung University,School of Pharmacy, National Cheng Kung University Hospital, College of Medicine
[2] Chia-Nan University of Pharmacy and Science,Department of Pharmacy
[3] Chang Gung University,Graduate Institute of Natural Products, College of Medicine
[4] College of Human Ecology,Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology
[5] Chang Gung University of Science and Technology,Department of Anesthesiology
[6] Chang Gung Memorial Hospital,Department of Biotechnology
[7] Southern Taiwan University of Science and Technology,Department of Pharmacy
[8] Tajen University,Department of Chemistry
[9] Vinh University,undefined
来源：
Journal of Natural Medicines | 2017年 / 71卷
关键词：
Clausenalansamide; Electronic circular dichroism; Single-crystal X-ray diffraction analysis; Anti-inflammatory; Superoxide anion generation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.
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页码：96 / 104
页数：8
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