IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma

[1] Asao H(2001)Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex J Immunol 167 1-5

[2] Okuyama C(2001)Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system J Clin Oncol 19 3622-3634

[3] Kumaki S(2001)Final version of the American joint committee on cancer staging system for cutaneous melanoma J Clin Oncol 19 3635-3648

[4] Ishii N(2004)IL-21 Induces the functional maturation of murine NK Cells J Immunol 172 2048-2058

[5] Tsuchiya S(1994)Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation J Immunol 153 1430-1440

[6] Foster D(1983)Interferon induction of fibroblast proteins with guanylate binding activity J Biol Chem 258 7746-7750

[7] Sugamura K(2004)T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells J Immunol 173 68-78

[8] Balch CM(2007)IL-21 Is produced by NKT cells and modulates NKT cell activation and cytokine production J Immunol 178 2827-2834

[9] Soong SJ(2007)An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma Clin Cancer Res 13 3630-3636

[10] Gershenwald JE(1997)Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma Oncogene 15 453-457

[1] Asao H(2001)Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex J Immunol 167 1-5

[2] Okuyama C(2001)Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system J Clin Oncol 19 3622-3634

[3] Kumaki S(2001)Final version of the American joint committee on cancer staging system for cutaneous melanoma J Clin Oncol 19 3635-3648

[4] Ishii N(2004)IL-21 Induces the functional maturation of murine NK Cells J Immunol 172 2048-2058

[5] Tsuchiya S(1994)Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation J Immunol 153 1430-1440

[6] Foster D(1983)Interferon induction of fibroblast proteins with guanylate binding activity J Biol Chem 258 7746-7750

[7] Sugamura K(2004)T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells J Immunol 173 68-78

[8] Balch CM(2007)IL-21 Is produced by NKT cells and modulates NKT cell activation and cytokine production J Immunol 178 2827-2834

[9] Soong SJ(2007)An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma Clin Cancer Res 13 3630-3636

[10] Gershenwald JE(1997)Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma Oncogene 15 453-457