Effects of Miramistin and Phosprenil on Microbial Biofilms

被引：0

作者：

T. A. Danilova

G. A. Danilina

A. A. Adzhieva

A. G. Minko

T. N. Nikolaeva

V. G. Zhukhovitskii

A. V. Pronin

机构：

[1] Laboratory of Indication and Ultrastructural Analysis of Microorganisms,

[2] Laboratory of Natural Immunity,undefined

[3] N. F. Gamaleya Federal Research Centre of Epidemiology and Microbiology,undefined

[4] Ministry of Health of the Russian Federation,undefined

[5] I. M. Sechenov First Moscow State Medical University,undefined

[6] Ministry of Health of the Russian Federation,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2017年 / 163卷

关键词：

microorganisms; biofilms; Miramistin; Phosprenil;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Effects of Miramistin and Phosprenil on biofilms of S. pyogenes, S. aureus, E. coli, L. acidophilus, and L. plantarum were studied. Significant differences in the effects of these substances on mature biofilms of microorganisms and the process of their formation were observed. Miramistin had significant inhibiting effects on the forming of biofilms and on the formed biofilms of all studied microorganisms. Treatment with Miramistin inhibited biofilm formation by 2-3 times compared to the control. This effect was found already after using of Miramistin in the low doses (3.12 μg/ml). Inhibition of the growth of a formed biofilm was observed only after treatment with Miramistin in the high doses (25-50 μg/ml). Phosprenil in the high doses (15-30 mg/ml) inhibited the forming of biofilms, especially the biofilms of S. pyogenes and L. plantarum (by 3-4.5 times). Treatment of formed biofilms with the agent in doses of 6.0 and 0.6 mg/ml was associated with pronounced stimulation of its growth in S. pyogenes, S. aureus, and L. acidophilus.

引用

页码：439 / 442

页数：3

共 46 条

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