Ezetimibe/Simvastatin: A Guide to its Clinical Use in Hypercholesterolemia

被引：0
作者：
Katherine A. Lyseng-Williamson
机构：
[1] Adis,
[2] a Wolters Kluwer Business,undefined
来源：
American Journal of Cardiovascular Drugs | 2012年 / 12卷
关键词：
Chronic Kidney Disease; Statin; Simvastatin; Atorvastatin; Statin Therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Ezetimibe/simvastatin therapy combines two lipid-lowering compounds with complementary mechanisms of action, thereby blocking the two sources of plasma cholesterol and improving lipid profiles. Ezetimibe/simvastatin is an effective and generally well tolerated adjunct to dietary therapy for markedly reducing lowdensity lipoprotein cholesterol (LDL-C) levels and improving other lipid parameters across diverse patient populations. Dual treatment with ezetimibe/simvastatin is more effective than monotherapy with an HMG-CoA reductase inhibitor (statin), and the addition of ezetimibe to current statin therapy is more effective than doubling the statin dose.
引用
收藏
页码：49 / 56
页数：7
相关论文
共 50 条
[41]   Increasing Doses of Simvastatin Versus Combined Ezetimibe/Simvastatin: Effect on Circulating Endothelial Progenitor Cells [J].
Pesaro, Antonio Eduardo P. ;
Serrano, Carlos V., Jr. ;
Katz, Marcelo ;
Marti, Luciana ;
Fernandes, Juliano L. ;
Parra, Paulo R. G. ;
Campos, Alexandre H. .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2013, 18 (05) :447-452
[42]   Ezetimibe/simvastatin (INEGY™) in the treatment of hyperlipidaemia [J].
Kastelein, JJP ;
Sankatsing, RR .
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (12) :1464-1471
[43]   A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin & Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial [J].
Hong, Soon Jun ;
Jeong, Han Saem ;
Ahn, Jeong Cheon ;
Cha, Dong-Hun ;
Won, Kyung Heon ;
Kim, Weon ;
Cho, Sang Kyoon ;
Kim, Seok-Yeon ;
Yoo, Byung-Su ;
Sung, Ki Chul ;
Rha, Seung-Woon ;
Shin, Joon-Han ;
Han, Kyoo Rok ;
Chung, Wook Sung ;
Hyon, Min Su ;
Lee, Han Cheol ;
Bae, Jang-Ho ;
Rhee, Moo-Yong ;
Kwan, Jun ;
Jeon, Dong Woon ;
Yoo, Ki Dong ;
Kim, Hyo-Soo .
CLINICAL THERAPEUTICS, 2018, 40 (02) :226-241
[44]   Clinical benefits of ezetimibe use: is absence of proof, proof of absence? [J].
Gouni-Berthold, Ioanna ;
Mikhailidis, Dimitri P. ;
Rizzo, Manfredi .
EXPERT OPINION ON PHARMACOTHERAPY, 2012, 13 (14) :1985-1988
[45]   Simvastatin-induced thrombocytopaenia: a further case and a brief on its clinical relevance [J].
Ames, P. R. J. .
ANNALS OF HEMATOLOGY, 2008, 87 (09) :773-774
[46]   Simvastatin-induced thrombocytopaenia: a further case and a brief on its clinical relevance [J].
P. R. J. Ames .
Annals of Hematology, 2008, 87 :773-774
[47]   Efficacy and safety of ezetimibe/simvastatin association on non-diabetic and diabetic patients with polygenic hypercholesterolemia or combined hyperlipidemia and previously intolerant to standard statin treatment [J].
Derosa, G. ;
D'Angelo, A. ;
Franzetti, I. G. ;
Ragonesi, P. D. ;
Gadaleta, G. ;
Scalise, F. ;
Ciccarelli, L. ;
Piccinni, M. N. ;
Cicero, A. F. G. .
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2009, 34 (03) :267-276
[48]   Ezetimibe - a new approach in hypercholesterolemia management [J].
Kostapanos, Michael S. ;
Elisaf, Moses S. ;
Mikhailidis, Dimitri P. .
PHARMACOLOGICAL REPORTS, 2012, 64 (04) :997-998
[49]   Real-world data to assess changes in low-density lipoprotein cholesterol and predicted cardiovascular risk after ezetimibe discontinuation post reporting of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression trial [J].
Bays, Harold E. ;
Patel, Mehul D. ;
Mavros, Panagiotis ;
Ramey, Dena R. ;
Tomassini, Joanne E. ;
Tershakovec, Andrew M. ;
Baxter, Carl A. .
JOURNAL OF CLINICAL LIPIDOLOGY, 2017, 11 (04) :929-937
[50]   Combination of bempedoic acid, ezetimibe, and atorvastatin in patients with hypercholesterolemia: A randomized clinical trial [J].
Rubino, John ;
MacDougall, Diane E. ;
Sterling, Lulu R. ;
Hanselman, Jeffrey C. ;
Nicholls, Stephen J. .
ATHEROSCLEROSIS, 2021, 320 :122-128
12345