Ezetimibe/Simvastatin: A Guide to its Clinical Use in Hypercholesterolemia

被引：0
作者：
Katherine A. Lyseng-Williamson
机构：
[1] Adis,
[2] a Wolters Kluwer Business,undefined
来源：
American Journal of Cardiovascular Drugs | 2012年 / 12卷
关键词：
Chronic Kidney Disease; Statin; Simvastatin; Atorvastatin; Statin Therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Ezetimibe/simvastatin therapy combines two lipid-lowering compounds with complementary mechanisms of action, thereby blocking the two sources of plasma cholesterol and improving lipid profiles. Ezetimibe/simvastatin is an effective and generally well tolerated adjunct to dietary therapy for markedly reducing lowdensity lipoprotein cholesterol (LDL-C) levels and improving other lipid parameters across diverse patient populations. Dual treatment with ezetimibe/simvastatin is more effective than monotherapy with an HMG-CoA reductase inhibitor (statin), and the addition of ezetimibe to current statin therapy is more effective than doubling the statin dose.
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页码：49 / 56
页数：7
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