Adenovirus-mediated VEGF165 gene transfer enhances wound healing by promoting angiogenesis in CD1 diabetic mice

被引：0

作者：

S Romano Di Peppe

A Mangoni

G Zambruno

G Spinetti

G Melillo

M Napolitano

M C Capogrossi

机构：

[1] Laboratorio di Patologia Vascolare,

[2] Istituto Dermopatico dell'Immacolata,undefined

[3] Istituto di Ricovero e Cura a Carattere Scientifico,undefined

[4] Laboratorio di Biologia Molecolare e Cellulare,undefined

[5] Istituto Dermopatico dell'Immacolata,undefined

[6] Istituto di Ricovero e Cura a Carattere Scientifico,undefined

[7] Laboratorio di Biologia Vascolare e Terapia Genica,undefined

[8] Centro Cardiologico Fondazione ‘I Monzino’,undefined

[9] IRCCS,undefined

来源：

Gene Therapy | 2002年 / 9卷

关键词：

VEGF; gene therapy; wound healing; diabetes;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

It has been previously shown that vascular endothelial growth factor (VEGF) plays a central role in promoting angiogenesis during wound repair and that healing-impaired diabetic mice show decreased VEGF expression levels. In order to investigate the potential benefits of gene therapy with growth factors on wound repair, a replication-deficient recombinant adenovirus vector carrying the human VEGF165 gene (AdCMV.VEGF165) was topically applied on excisional wounds of streptozotocin-induced diabetic mice. Treatment with AdCMV.VEGF165 significantly accelerated wound closure when compared with AdCMV.LacZ-treated, as well as saline-treated control mice, by promoting angiogenesis at the site of injury. Our findings suggest that AdCMV.VEGF165 may be regarded as a therapeutic tool for the treatment of diabetic ulcers.

引用

页码：1271 / 1277

页数：6

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