Interactions between FLG mutations and allergens in atopic dermatitis

被引：0
作者：
Ming Li
Jiang-Bo Liu
Qiang Liu
Mianzhi Yao
Ruhong Cheng
Hui Xue
Hua Zhou
Zhirong Yao
机构：
[1] Shanghai Jiaotong University School of Medicine,Department of Dermatology, Xinhua Hospital
[2] Bao’an Maternal and Child Health Hospital,Department of Dermatology
[3] Shanxi Provincial Children’s Hospital,Department of Dermatology
[4] Central Laboratory,undefined
[5] Bao’an Maternal and Child Health Hospital,undefined
来源：
Archives of Dermatological Research | 2012年 / 304卷
关键词：
Atopic dermatitis; Filaggrin gene; Mutations; Sensitization; Allergen;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Filaggrin gene (FLG) mutations and sensitization in patients with atopic dermatitis (AD) have been well documented. However, whether an interaction exists between these mutations and specific sensitization in AD patients is still unknown. The aim of the study was to explore the interaction between FLG mutations and specific sensitization in AD patients. A total of 249 AD outpatients were recruited in the current study. Skin prick tests were conducted to assess the patient’s sensitization to specific allergens. FLG mutations were analyzed through comprehensive sequencing. Logistic regression analyses were conducted to determine the interactions between FLG mutations and sensitization present. The mean age of the patients was 3.5 years, and the mean age of onset of AD was 9.6 months. The mean SCORAD of the patients was 25.8. Fourteen types of mutations were identified in the FLG of 64 patients. A total of 24 (9.6 %) and 29 (11.6 %) cases were mutated with 3321delA and K4671X, respectively. Sensitization to at least one type of allergen was detected in 118 patients (47.4 %). Logistic regression analyses showed that FLG mutations presented an interaction with sensitization to peanut and did not interact with the other detected allergens among AD patients. Sensitization to peanut allergens would have an interaction with the mutation of K4671X and the combined mutations in FLG in patients with atopic dermatitis. However, sensitization to the other common allergens might not interact with FLG mutations in the development of atopic dermatitis.
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页码：787 / 793
页数：6
相关论文
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