Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam

被引：0

作者：

Zhou, Yuan-Yuan ^{[1
]}

Sun, Zhao ^{[1
]}

Liu, Yan ^{[1
]}

Fang, Zhen-Xing ^{[2
]}

Gao, Hui-Rui ^{[1
]}

Liu, Ning-Yu ^{[1
]}

Zhang, Xiao-Juan ^{[3
]}

Yang, Bing-You ^{[1
]}

Kuang, Hai-Xue ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Key Lab Basic & Applicat Res Beiyao, Minist Educ, Harbin 150040, Peoples R China

[2] Heilongjiang Acad Sci, Inst Nat & Ecol, Harbin 150040, Peoples R China

[3] Heilongjiang Univ Tradit Chinese Med, Acad Res Dept, Harbin 150040, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2024年 / 78卷 / 03期

关键词：

Atractylodes japonica Koidz; Ex Kitam; Sesterterpenoids; Structure elucidation; Cytotoxic activities; SESQUITERPENE LACTONES; RHIZOMES; EXTRACT; SKI3246;

D O I：

10.1007/s11418-024-01793-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten known compounds (3-12). Their structures were elucidated on the basis of comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS and IR). In addition, all of these isolated compounds were evaluated for their cytotoxic activities against human gastric cancer cell MGC-803 and human hepatocellular cancer cell HepG-2. Most of them exhibited moderate to weak inhibitory effects with IC(50 )values in the range of 25.15-88.85 mu M except for 9-12.

引用

页码：702 / 708

页数：7

共 19 条

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