Oxidative Stress and S100B Protein in Cirrhotic Children

被引：0
作者：
Luciana Ribeiro
Ana Cristina Andreazza
Mirian Salvador
Themis Reverbel da Silveira
Sandra Vieira
Daniel Bocchese Nora
Cleonice Bosa
Francesca Di Napoli
Débora Vigevani Schaf
Diogo Onofre Souza
Luis Valmor Cruz Portela
Flávio Kapczinski
机构：
[1] Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul,Laboratório de Psiquiatria Experimental
[2] Instituto de Biotecnologia da Universidade de Caxias do Sul,Unidade de Gastroenterologia Pediátrica
[3] Hospital de Clínicas de Porto Alegre,Serviço de Neurologia
[4] Hospital de Clínicas de Porto Alegre,Instituto de Psicologia, Departamento de Psicologia do Desenvolvimento
[5] Universidade Federal do Rio Grande do Sul,Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde
[6] Universidade Federal do Rio Grande do Sul,undefined
来源：
Neurochemical Research | 2007年 / 32卷
关键词：
Cirrhosis; Liver disease; Children; Oxidative stress; S100B protein;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted a case-control study to assess the serum levels of S100B protein and parameters of oxidative stress, superoxide dismutase (SOD), catalase (CAT) and oxidative stress measured by the thiobarbituric acid method (TBARS), in a group of 14 pediatric patients with cirrhosis. No differences were found between groups in S100B protein levels. SOD activity and TBARS levels were higher; and CAT activity was lower in the cirrhotic group. A negative correlation between S100B and TBARS in the case group was found (r = −0.815, p = 0.001). Conclusions: This study didn’t indicate a possible role of S100B serum levels as marker of brain damage in cirrhotic children but suggest a possible relation between astrocyte function and oxidative damage in cirrhotic children.
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页码：1600 / 1603
页数：3
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