Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection

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作者
Saiaditya Badeti
Qingkui Jiang
Alireza Naghizadeh
Hsiang-chi Tseng
Yuri Bushkin
Salvatore A. E. Marras
Annuurun Nisa
Sanjay Tyagi
Fei Chen
Peter Romanienko
Ghassan Yehia
Deborah Evans
Moises Lopez-Gonzalez
David Alland
Riccardo Russo
William Gause
Lanbo Shi
Dongfang Liu
机构
[1] Rutgers University,Department of Pathology, Immunology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers
[2] Rutgers University,New Jersey Medical School
[3] Rutgers University,School of Graduate Studies, Biomedical and Health Sciences
[4] Rutgers University,Center for Immunity and Inflammation, New Jersey Medical School
[5] Regional Bio-Containment Laboratory,Public Health Research Institute, New Jersey Medical School
[6] Center for COVID-19 Response and Pandemic Preparedness (CCRP2),Genome Editing Shared Resources, Cancer Institute of New Jersey
[7] Rutgers-New Jersey Medical School,undefined
[8] Rutgers University,undefined
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关键词
CD147; Basigin; hCD147KI; NSG; SARS-CoV-2; COVID-19; Viral entry; Accessory receptor; Immune responses; Spike protein; Knock-in mouse model; Physiological expression;
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