Primary malignant melanoma of the lung with rapid progression

被引：25

作者：

Maeda R. ^{[1
]}

Isowa N. ^{[1
]}

Onuma H. ^{[2
]}

Miura H. ^{[2
]}

Tokuyasu H. ^{[3
]}

Kawasaki Y. ^{[3
]}

机构：

[1] Division of Thoracic Surgery, Matsue Red Cross Hospital, Matsue, Shimane 690-8506

[2] Division of Pathology, Matsue Red Cross Hospital, Shimane

[3] Division of Respiratory Medicine, Matsue Red Cross Hospital, Shimane

来源：

General Thoracic and Cardiovascular Surgery | 2009年 / 57卷 / 12期

关键词：

Lung neoplasm; Malignant melanoma; Surgery;

D O I：

10.1007/s11748-009-0454-9

中图分类号：

学科分类号：

摘要：

This report presents a case of primary malignant melanoma of the lung with rapid progression in a 68-year-old man. During a regular checkup, a chest roentgenogram revealed an abnormal shadow in the left lower lung field. Computed tomography (CT) of the chest revealed an ill-defined tumor shadow measuring 4 × 3 cm in the left upper lobe. A CT-guided lung biopsy suggested a large-cell carcinoma, and left upper lobectomy was performed. Histopathologically, the tumor was comprised of malignant epithelial tumor cells with large amounts of acidophilic cytoplasm and prominent nuclei. A dark brown pigment was observed in the tumor cells. Immunohistochemical staining was positive for S-100 protein and HMB45; staining for cytokeratin, CAM5.2, and chromogranin was negative. The final diagnosis was malignant melanoma of the lung. Two months later, multiple brain metastases developed, and he died of the disease 6 months after the surgery. © 2009 The Japanese Association for Thoracic Surgery.

引用

页码：671 / 674

页数：3

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