Demethylating agent decitabine disrupts tumor-induced immune tolerance by depleting myeloid-derived suppressor cells

被引:0
作者
Jihao Zhou
Yushi Yao
Qi Shen
Guoqiang Li
Lina Hu
Xinyou Zhang
机构
[1] Jinan University,Department of Hematology, The Second Clinical Medical College (Shenzhen People’s Hospital)
[2] McMaster University,McMaster Immunology Research Centre
来源
Journal of Cancer Research and Clinical Oncology | 2017年 / 143卷
关键词
Decitabine; Demethylation; Myeloid-derived suppressor cells; Immune tolerance; Immunotherapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1371 / 1380
页数:9
相关论文
共 110 条
[1]  
Almstedt M(2010)The DNA demethylating agent 5-aza-2 ‘-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells Leuk Res 34 899-905
[2]  
Blagitko-Dorfs N(2011)MAGE-A1, MAGE-A3, and NY-ESO-1 can be upregulated on neuroblastoma cells to facilitate cytotoxic T lymphocyte-mediated tumor cell killing Cancer Immunol Immunother 60 1299-1307
[3]  
Duque-Afonso J(2007)Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines Leuk Res 31 497-506
[4]  
Karbach J(2014)Exosomes from myeloid-derived suppressor cells carry biologically active proteins J Proteome Res 13 836-843
[5]  
Pfeifer D(2014)Low-dose 5-aza-2′-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells Mol Med 20 248-256
[6]  
Jaeger E(2010)In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia Blood 116 129-139
[7]  
Luebbert M(2010)Generation of antigen-presenting cells from tumor-infiltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2′-deoxycytidine. Cancer Immunol Immunother 59 697-706
[8]  
Bao L(2016)Improving cancer immunotherapy by targeting the STATe of MDSCs Oncoimmunology 5 e1196312-3356
[9]  
Dunham K(2005)DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling Development 132 3345-5747
[10]  
Lucas K(2014)The role of myeloid-derived suppressor cells in immune ontogeny Front Immunol 5 387-1131