Quantifying the added value of new biomarkers: how and how not

被引：132
作者：
Nancy R. Cook
机构：
[1] Harvard Medical School,Division of Preventive Medicine, Brigham and Women’s Hospital
来源：
Diagnostic and Prognostic Research | / 2卷 / 1期
关键词：
Biomarkers; Model fit; Calibration; Reclassification; Clinical utility;
D O I：
10.1186/s41512-018-0037-2
中图分类号：
学科分类号：
摘要：
Over the past few decades, interest in biomarkers to enhance predictive modeling has soared. Methodology for evaluating these has also been an active area of research. There are now several performance measures available for quantifying the added value of biomarkers. This commentary provides an overview of methods currently used to evaluate new biomarkers, describes their strengths and limitations, and offers some suggestions on their use.
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