The immune network in pancreatic cancer development and progression

被引：0
作者：
S M Wörmann
K N Diakopoulos
M Lesina
H Algül
机构：
[1] Medizinische Klinik,
[2] Klinikum rechts der Isar,undefined
[3] Technische Universität München,undefined
来源：
Oncogene | 2014年 / 33卷
关键词：
pancreatic ductal adenocarcinoma; tumor microenvironment; immune system; cytokines; pattern recognition receptors; immune cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The presence of stromal desmoplasia is a hallmark of spontaneous pancreatic ductal adenocarcinoma, forming a unique microenvironment that comprises many cell types. Only recently, the immune system has entered the pathophysiology of pancreatic ductal adenocarcinoma development. Tumor cells in the pancreas seem to dysbalance the immune system, thus facilitating spontaneous cancer development. This review will try to assemble all relevant data to demonstrate the implications of the immune network on spontaneous cancer development.
引用
收藏
页码：2956 / 2967
页数：11
相关论文
共 933 条
[1]  
Balkwill F(2001)Inflammation and cancer: back to Virchow? Lancet 357 539-545
[2]  
Mantovani A(2012)Accessories to the crime: functions of cells recruited to the tumor microenvironment Cancer Cell 21 309-322
[3]  
Hanahan D(2007)Mechanisms of disease: chronic inflammation and cancer in the pancreas–a potential role for pancreatic stellate cells? Nat Clin Pract Gastroenterol Hepatol 4 454-462
[4]  
Coussens LM(2010)Pancreatic cancer N Engl J med 362 1605-1617
[5]  
Algul H(2003)2. Cytokines and chemokines J Allergy Clin Immunol 111 S460-S475
[6]  
Treiber M(1999)Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer Clin Sci (Lond) 96 83-87
[7]  
Lesina M(2004)Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis Cancer 101 2727-2736
[8]  
Schmid RM(2009)Pro-inflammatory cytokine release by peripheral blood mononuclear cells from patients with advanced pancreatic cancer: relationship to acute phase response and survival Oncol Rep 21 1091-1095
[9]  
Hidalgo M(2010)Diagnostic usefulness of serum interleukin 6 (IL-6) and C-reactive protein (CRP) in the differentiation between pancreatic cancer and chronic pancreatitis J Clin Lab Anal 24 256-261
[10]  
Borish LC(2002)Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer Int J Oncol 21 881-886
12345678910