Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor

被引：0

作者：

Jiantao Zhao

Christopher Sauvage

Jinghua Zhao

Frédérique Bitton

Guillaume Bauchet

Dan Liu

Sanwen Huang

Denise M. Tieman

Harry J. Klee

Mathilde Causse

机构：

[1] INRA,MRC Epidemiology Unit & Institute of Metabolic Science

[2] UR1052,Genome Analysis Laboratory of the Ministry of Agriculture

[3] Génétique et Amélioration des Fruits et Légumes,Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture, Sino

[4] Domaine Saint Maurice,Dutch Joint Laboratory of Horticultural Genomics

[5] University of Cambridge,Horticultural Sciences, Plant Innovation Center

[6] Addrenbrooke’s Hospital,Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory

[7] Agricultural Genomics Institute at Shenzhen,undefined

[8] Chinese Academy of Agricultural Sciences,undefined

[9] Institute of Vegetables and Flowers,undefined

[10] Chinese Academy of Agricultural Sciences,undefined

[11] University of Florida,undefined

[12] Syngenta,undefined

[13] 12 Chemin de l’Hobit,undefined

[14] University of Cambridge,undefined

[15] Boyce Thompson Institute,undefined

[16] Cornell University,undefined

来源：

Nature Communications | / 10卷

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摘要：

Tomato flavor has changed over the course of long-term domestication and intensive breeding. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies (GWAS) using 775 tomato accessions and 2,316,117 SNPs from three GWAS panels. We discover 305 significant associations for the contents of sugars, acids, amino acids, and flavor-related volatiles. We demonstrate that fruit citrate and malate contents have been impacted by selection during domestication and improvement, while sugar content has undergone less stringent selection. We suggest that it may be possible to significantly increase volatiles that positively contribute to consumer preferences while reducing unpleasant volatiles, by selection of the relevant allele combinations. Our results provide genetic insights into the influence of human selection on tomato flavor and demonstrate the benefits obtained from meta-analysis.

引用

共 125 条

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