Functional roles of connexins and pannexins in the kidney

被引:0
作者
Ahmed B. Abed
Panagiotis Kavvadas
Christos E. Chadjichristos
机构
[1] INSERM UMR-S1155,
[2] Batiment Recherche,undefined
[3] Tenon Hospital,undefined
[4] Sorbonne Universite´s,undefined
[5] UPMC Univ Paris 6,undefined
来源
Cellular and Molecular Life Sciences | 2015年 / 72卷
关键词
Connexin; Pannexin; Renal physiology;
D O I
暂无
中图分类号
学科分类号
摘要
Kidneys are highly complex organs, playing a crucial role in human physiopathology, as they are implicated in vital processes, such as fluid filtration and vasomotor tone regulation. There is growing evidence that gap junctions are major determinants of renal physiopathology. It has been demonstrated that their expression or channel activity may vary depending on physiological and pathological situations within distinct renal compartments. While some studies have focused on the role of connexins in renal physiology, our knowledge regarding the functional relevance of pannexins is still very limited. In this paper, we provide an overview of the involvement of connexins, pannexins and their channels in various physiological processes related to different renal compartments.
引用
收藏
页码:2869 / 2877
页数:8
相关论文
共 422 条
[1]  
Biava C(1966)Fine structure of normal human juxtaglomerular cells. I. General structure and intercellular relationships Am J Pathol 49 679-721
[2]  
West M(1975)Studies on the juxtaglomerular apparatus. IV. Freeze-fracturing of membrane surfaces Cell Tissue Res 161 459-469
[3]  
Boll HU(1974)Gap junctions in mesangial and lacis cells J Cell Biol 63 349-354
[4]  
Forssmann WG(1984)Interendothelial junctions in kidney vessels Cell Tissue Res 236 567-576
[5]  
Taugner R(1984)Myoendothelial contacts in glomerular arterioles and in renal interlobular arteries of rat, mouse and Tupaia belangeri Cell Tissue Res 235 319-325
[6]  
Pricam C(1994)Immunochemical characterization of the gap junction protein connexin45 in mouse kidney and transfected human HeLa cells J Membr Biol 141 247-256
[7]  
Humbert F(2005)Differential connexin expression in preglomerular and postglomerular vasculature: accentuation during diabetes Kidney Int 68 1171-1185
[8]  
Perrelet A(2008)Function of connexins in the renal circulation Kidney Int 73 547-555
[9]  
Orci L(1997)Upregulation and co-localization of connexin43 and cellular adhesion molecules in inflammatory renal disease J Pathol 182 373-379
[10]  
Mink D(2006)Redistribution of connexin43 expression in glomerular podocytes predicts poor renal prognosis in patients with type 2 diabetes and overt nephropathy Nephrol Dial Transplant 21 2472-2477