Integrated testing and intelligent assessment—new challenges under REACH

被引:0
|
作者
Jan Ahlers
Frauke Stock
Barbara Werschkun
机构
[1] Umweltbundesamt,
[2] Umweltbundesamt,undefined
[3] Bundesinstitut für Risikobewertung,undefined
来源
Environmental Science and Pollution Research | 2008年 / 15卷
关键词
Chemicals; Ecotoxicity; Integrated assessment; In vitro testing; In vivo testing; Modes of action; QSAR; REACH; Read-across; Regulation; Risk assessment; Testing strategies; Toxicity; Weight of evidence;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:565 / 572
页数:7
相关论文
共 50 条
  • [31] Non-testing approaches under REACH - help or hindrance? Perspectives from a practitioner within industry
    Patlewicz, G.
    Chen, M. W.
    Bellin, C. A.
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2011, 22 (1-2) : 67 - 88
  • [32] Integrated Decision-tree Testing Strategies for Acute Systemic Toxicity and Toxicokinetics with Respect to the Requirements of the EU REACH Legislation
    Cornbes, Robert
    Grindon, Christina
    Cronin, Mark T. D.
    Roberts, David W.
    Garrod, John F.
    ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2008, 36 : 91 - 109
  • [33] An Integrated Decision-tree Testing Strategy for Repeat Dose Toxicity with Respect-to the Requirements of the EU REACH Legislation
    Grindon, Christina
    Cornbes, Robert
    Cronin, Mark T. D.
    Roberts, David W.
    Garrod, John F.
    ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2008, 36 : 139 - 147
  • [34] Integrated decision-tree testing strategies for acute systemic toxicity and Toxicokinetics with respect to the requirements of the EU REACH legislation
    Combes, Robert
    Grindon, Christina
    Cronin, Mark T. D.
    Roberts, David W.
    Garrod, John F.
    ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2008, 36 (01): : 45 - 63
  • [35] Alternative methods to animal experiments. What can they afford in the safety testing of chemical substances under REACH?
    Lilienblum, W.
    BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ, 2008, 51 (12) : 1434 - 1443
  • [36] Use of read-across and tiered exposure assessment in risk assessment under REACH - A case study on a phase-in substance
    Vink, S. R.
    Mikkers, J.
    Bouwman, T.
    Marquart, H.
    Kroese, E. D.
    REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2010, 58 (01) : 64 - 71
  • [37] Testing and risk assessment of persistent and bioaccumulating chemical substances -: Improvements within REACH?
    Breitholtz, Magnus
    Eriksson, Johan
    Green, Nicholas
    Ruden, Christina
    HUMAN AND ECOLOGICAL RISK ASSESSMENT, 2006, 12 (04): : 782 - 805
  • [38] Integrated Approaches to Testing and Assessment
    Worth, Andrew P.
    Patlewicz, Grace
    VALIDATION OF ALTERNATIVE METHODS FOR TOXICITY TESTING, 2016, 856 : 317 - 342
  • [39] Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)
    Tollefsen, Knut Erik
    Scholz, Stefan
    Cronin, Mark T.
    Edwards, Stephen W.
    de Knecht, Joop
    Crofton, Kevin
    Garcia-Reyero, Natalia
    Hartung, Thomas
    Worth, Andrew
    Patlewicz, Grace
    REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2014, 70 (03) : 629 - 640
  • [40] Beyond REACH: Roadblocks and shortcuts en route to integrated risk assessment and management of chemicals
    Assmuth, Timo
    Hilden, Mikael
    Craye, Matthieu
    SCIENCE OF THE TOTAL ENVIRONMENT, 2010, 408 (18) : 3954 - 3963