Associations Between the Lead Level in Maternal Blood and Umbilical Cord Blood and Congenital Heart Diseases in Offspring

被引：0
作者：
Lei Huang
Baohong Mao
Jiayue Li
Nan Nan
Li He
Jie Qiu
Bin Yi
Qing Liu
机构：
[1] Gansu Provincial Maternity and Child Care Hospital,
来源：
Biological Trace Element Research | 2023年 / 201卷
关键词：
Congenital heart disease; Lead exposure; Birth defects; Cardiac development;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The incidence of congenital heart diseases (CHDs) shows an increasing trend and results in large health burdens in China. However, there have been inconsistent results of the relationship between lead (Pb) level and risk of CHDs. We performed a pair-matched case–control study and included 97 cases and 194 controls to investigate the association between pregnancy Pb exposure and the risk of CHDs in a birth cohort study conducted in Lanzhou, China. The results showed that compared to the lowest Pb tertile, both highest tertile levels of maternal blood and umbilical cord blood Pb were associated with an increased risk of CHDs. The similar significant results were found in cases with isolated CHDs. Compared to both lowest tertiles of Pb level in maternal blood and umbilical cord blood, the highest tertile was associated with an increased risk of CHDs, especially for isolated CHDs. Overall, our study suggests a significant association between pregnancy Pb exposure and risk of CHDs, especially for isolated CHDs. Future studies are needed to elucidate the underlying mechanism.
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页码：2191 / 2199
页数：8
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