Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: Report of the Indian Society of Gastroenterology Task Force

被引：54

作者：

Bhatia S.J. ^{[1
]}

Reddy D.N. ^{[1
]}

Ghoshal U.C. ^{[1
]}

Jayanthi V. ^{[1
]}

Abraham P. ^{[1
]}

Choudhuri G. ^{[1
]}

Broor S.L. ^{[1
]}

Ahuja V. ^{[1
]}

Augustine P. ^{[1
]}

Balakrishnan V. ^{[1
]}

Bhasin D.K. ^{[1
]}

Bhat N. ^{[1
]}

Chacko A. ^{[1
]}

Dadhich S. ^{[1
]}

Dhali G.K. ^{[1
]}

Dhawan P.S. ^{[1
]}

Dwivedi M. ^{[1
]}

Goenka M.K. ^{[1
]}

Koshy A. ^{[1
]}

Kumar A. ^{[1
]}

Misra S.P. ^{[1
]}

Mukewar S. ^{[1
]}

Raju E.P. ^{[1
]}

Shenoy K.T. ^{[1
]}

Singh S.P. ^{[1
]}

Sood A. ^{[1
]}

Srinivasan R. ^{[1
]}

机构：

[1] Department of Gastroenterology, Seth G S Medical College and K E M Hospital

来源：

Indian Journal of Gastroenterology | 2011年 / 30卷 / 3期

关键词：

Asia; Epidemiology; Esophagus; Heartburn; Risk factors;

D O I：

10.1007/s12664-011-0112-x

中图分类号：

学科分类号：

摘要：

Background: Gastroesophageal reflux disease (GERD) and its complications are thought to be infrequent in India; there are no data from India on the prevalence of and risk factors for GERD. The Indian Society of Gastroenterology formed a task force aiming to study: (a) the frequency and profile of GERD in India, (b) factors including diet associated with GERD. Methods: In this prospective, multi-center (12 centers) study, data were obtained using a questionnaire from 3224 subjects regarding the frequency, severity and duration of heartburn, regurgitation and other symptoms of GERD. Data were also obtained regarding their dietary habits, addictions, and lifestyle, and whether any of these were related or had been altered because of symptoms. Data were analyzed using univariate and multivariate methods. Results: Two hundred and forty-five (7.6%) of 3224 subjects had heartburn and/or regurgitation at least once a week. On univariate analysis, older age (OR 1.012; 95% CI 1.003-1.021), consumption of non-vegetarian and fried foods, aerated drinks, tea/coffee were associated with GERD. Frequency of smoking was similar among subjects with or without GERD. Body mass index (BMI) was similar in subjects with and without GERD. On multivariate analysis, consumption of non-vegetarian food was independently associated with GERD symptoms. Overlap with symptoms of irritable bowel syndrome was not uncommon; 21% reported difficulty in passage of stool and 9% had mucus in stools. About 25% of patients had consulted a doctor previously for their gastrointestinal symptoms. Conclusion: 7.6% of Indian subjects have significant GERD symptoms. Consumption of non-vegetarian foods was an independent predictor of GERD. BMI was comparable among subjects with or without GERD. © 2011 Indian Society of Gastroenterology.

引用

页码：118 / 127

页数：9

共 35 条

[1] Chang C.S., Poon S.K., Lien H.C., Chen G.H., The incidence of reflux esophagitis among the Chinese, Am J Gastroenterol, 92, pp. 668-671, (1997)
[2] Cheung T.K., Wong B.C., Lam S.K., Gastro-oesophageal reflux disease in Asia: birth of a 'new' disease?, Drugs, 68, pp. 399-406, (2008)
[3] Cho Y.S., Choi M.G., Jeong J.J., Et al., Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea, Am J Gastroenterol, 100, pp. 747-753, (2005)
[4] Dent J., El-Serag H.B., Wallander M.A., Johansson S., Epidemiology of gastro-oesophageal reflux disease: a systematic review, Gut, 54, pp. 710-717, (2005)
[5] Terano A., The current status of GERD between the west and the east, J Gastroenterol, 38, SUPPL. 15, pp. 1-2, (2003)
[6] Ho K.Y., Kang J.Y., Seow A., Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux-type symptoms, Am J Gastroenterol, 93, pp. 1816-1822, (1998)
[7] Paranjape A.Y., Bhatia S.J., Mistry F.P., Abraham P., Prevalence of symptoms of gastroesophageal reflux disease (GERD) in the general population of Mumbai (Abstract), Indian J Gastroenterol, 15, SUPPL. 1, (1996)
[8] Somani S.K., Ghoshal U.C., Saraswat V.A., Et al., Correlation of esophageal pH and motor abnormalities with endoscopic severity of reflux esophagitis, Dis Esophagus, 17, pp. 58-62, (2004)
[9] Chourasia D., Misra A., Tripathi S., Krishnani N., Ghoshal U.C., Patients with H. pylori infection have less severe gastroesophageal reflux disease (GERD): A study using endoscopy, 24-hour gastric and esophageal pH metry, Indian J Gastroenterol, 30, pp. 12-21, (2011)
[10] Ghoshal U.C., Chourasia D., Gastroesophageal reflux disease and Helicobacter pylori: what may be the relationship?, J Neurogastroenterol Motil, 16, pp. 243-250, (2010)

← 1 2 3 4 →