Non-eosinophilic Asthma Endotypes

被引：1

作者：

Agache I. ^{[1
]}

机构：

[1] Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University, Brasov

来源：

Current Treatment Options in Allergy | 2015年 / 2卷 / 3期

关键词：

Asthma; Endotypes; Induced sputum; Innate immunity; Neutrophilic inflammation; Non-eosinophilic; Th17;

D O I：

10.1007/s40521-015-0052-2

中图分类号：

学科分类号：

摘要：

Several recent studies spanning from induced sputum to gene signature identified non-eosinophilic asthma (NEA) as a distinct asthma phenotype with several relevant clinical features such as increased asthma severity, increased remodelling and lower response to bronchodilator and anti-inflammatory treatment. Two major mechanisms leading to neutrophilic inflammation are postulated: the dysregulated innate immune response, including neutrophil intrinsic abnormalities, and the activation of the IL-17-dependent pathway. Several factors such as age, metabolic or epigenetic factors or the activation of the epithelial-mesenchimal trophic unit have been identified as modulators. The endotyping of NEA is far behind the eosinophilic asthma, and until now, no endotype-driven interventions have been proved to be effective. © 2015, Springer International Publishing AG.

引用

页码：257 / 267

页数：10

共 69 条

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