Non-eosinophilic Asthma Endotypes

被引：1
作者：
Agache I. [1 ]
机构：
[1] Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University, Brasov
来源：
Current Treatment Options in Allergy | 2015年 / 2卷 / 3期
关键词：
Asthma; Endotypes; Induced sputum; Innate immunity; Neutrophilic inflammation; Non-eosinophilic; Th17;
D O I：
10.1007/s40521-015-0052-2
中图分类号：
学科分类号：
摘要：
Several recent studies spanning from induced sputum to gene signature identified non-eosinophilic asthma (NEA) as a distinct asthma phenotype with several relevant clinical features such as increased asthma severity, increased remodelling and lower response to bronchodilator and anti-inflammatory treatment. Two major mechanisms leading to neutrophilic inflammation are postulated: the dysregulated innate immune response, including neutrophil intrinsic abnormalities, and the activation of the IL-17-dependent pathway. Several factors such as age, metabolic or epigenetic factors or the activation of the epithelial-mesenchimal trophic unit have been identified as modulators. The endotyping of NEA is far behind the eosinophilic asthma, and until now, no endotype-driven interventions have been proved to be effective. © 2015, Springer International Publishing AG.
引用
收藏
页码：257 / 267
页数：10
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