Dopexamine Maintains Mesenteric Blood Flow during Systemic Hypoxemia in the Neonatal Piglet

被引：5
作者：
Thomas T.V. [1 ]
Mace T.P. [1 ]
Choe E.U. [1 ]
Flint L.M. [1 ]
Ferrara J.J. [1 ,2 ]
机构：
[1] Department of Surgery, Tulane University School of Medicine, New Orleans, LA
[2] Department of Surgery SL-22, Tulane University School of Medicine, New Orleans, LA 70112
来源：
Journal of Gastrointestinal Surgery | 1997年 / 1卷 / 4期
关键词：
Dopexamine; Artery Blood Flow; Newborn Piglet; Aortic Blood Flow; Intestinal Blood Flow;
D O I：
10.1016/S1091-255X(97)80058-3
中图分类号：
学科分类号：
摘要：
In adults, dopexamine is a specific dopaminergic and β2-adrenergic agonist; its effects in neonates are unknown. Ultrasonic flow probes were placed around the ascending and descending aorta and cranial mesenteric artery of 0- to 2-day-old and 2-week-old piglets. Animals of each age group (9 to 14 per group) were subjected to (1) dopexamine infusion (5 μg/kg/min); (2) 30 minutes of hypoxia (inspired oxygen content 0.12) followed by 30 minutes of reoxygenation; and (3) dopexamine infusion during hypoxia and reoxygenation. In both age groups dopexamine alone increased ascending aorta blood flow (cardiac output minus coronary artery blood flow), mildly decreased mean arterial pressure, and increased cranial mesenteric artery blood flow. Compared to baseline values, 30 minutes of hypoxia produced significant (P <0.05, analysis of variance) decreases in cranial mesenteric artery blood flow in 0- to 2-day-old (58 ± 13 ml/min vs. 30 ± 8 ml/min) and 2-week-old (125 ± 18 ml/min vs. 60 ± 11 ml/min) piglets. In all cases blood flow returned to baseline values after reoxygenation. In both animal groups treated with dopexamine before hypoxia, the decreases in cranial mesenteric artery blood flow were eliminated (47 ± 5 ml/min vs. 44 ± 6 ml/min in 0- to 2-day-old piglets; 140 ± 27 ml/min vs. 117 ± 18 ml/min in 2-week-old piglets). Dopexamine may prove to be of clinical benefit when neonates are threatened by hypoxemia-induced decreases in intestinal blood flow.
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页码：362 / 370
页数：8
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