New trends in articular cartilage repair

被引：12
作者：
Cucchiarini M. [1 ,2 ]
Henrionnet C. [2 ,3 ]
Mainard D. [2 ,3 ]
Pinzano A. [2 ,3 ]
Madry H. [1 ,2 ,4 ]
机构：
[1] Center of Experimental Orthopaedics, Saarland University Medical Center and Saarland University, Bldg 37, Kirrbergerstr. 1, Homburg
[2] Cartilage Net of the Greater Region, Homburg
[3] Ingénierie Moléculaire et Physiopathologie Articulaire, Unité Mixte de Recherches 7365 Centre National de la Recherche Scientifique, Université de Lorraine, Vandoeuvre Lès Nancy
[4] Department of Orthopaedic Surgery, Saarland University Medical Center and Saarland University, Homburg/Saar
来源：
Journal of Experimental Orthopaedics | / 2卷 / 1期
关键词：
Bioengineering; Cartilage repair; Infrapatellar fat pad; Non-invasive second harmonic generation imaging; Osteoarthritis; rAAV gene therapy; Stem cells;
D O I：
10.1186/s40634-015-0026-0
中图分类号：
学科分类号：
摘要：
Damage to the articular cartilage is an important, prevalent, and unsolved clinical issue for the orthopaedic surgeon. This review summarizes innovative basic research approaches that may improve the current understanding of cartilage repair processes and lead to novel therapeutic options. In this regard, new aspects of cartilage tissue engineering with a focus on the choice of the best-suited cell source are presented. The importance of non-destructive cartilage imaging is highlighted with the recent availability of adapted experimental tools such as Second Harmonic Generation (SHG) imaging. Novel insights into cartilage pathophysiology based on the involvement of the infrapatellar fat pad in osteoarthritis are also described. Also, recombinant adeno-associated viral vectors are discussed as clinically adapted, efficient tools for potential gene-based medicines in a variety of articular cartilage disorders. Taken as a whole, such advances in basic research in diverse fields of articular cartilage repair may lead to the development of improved therapies in the clinics for an improved, effective treatment of cartilage lesions in a close future. © 2015, Cucchiarini et al.; licensee Springer.
引用
收藏
页码：1 / 8
页数：7
相关论文
共 73 条
  • [61] Teichtahl A.J., Wluka A.E., Wang Y., Hanna F., English D.R., Giles G.G., Cicuttini F.M., Obesity and adiposity are associated with the rate of patella cartilage volume loss over 2 years in adults without knee osteoarthritis, Ann Rheum Dis, 68, 6, pp. 909-913, (2009)
  • [62] Toda Y., Toda T., Takemura S., Wada T., Morimoto T., Ogawa R., Change in body fat, but not body weight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after a weight control program, J Rheumatol, 25, 11, pp. 2181-2186, (1998)
  • [63] Tritz-Schiavi J., Charif N., Henrionnet C., de Isla N., Bensoussan D., Magdalou J., Benkirane-Jessel N., Stoltz J.F., Huselstein C., Original approach for cartilage tissue engineering with mesenchymal stem cells, Biomed Mater Eng, 20, 3, pp. 167-174, (2010)
  • [64] Ushiyama T., Chano T., Inoue K., Matsusue Y., Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids, Ann Rheum Dis, 62, 2, pp. 108-112, (2003)
  • [65] Venkatesan J.K., Ekici M., Madry H., Schmitt G., Kohn D., Cucchiarini M., SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells, Stem Cell Res Ther, 3, 3, (2012)
  • [66] Venkatesan J.K., Rey-Rico A., Schmitt G., Wezel A., Madry H., Cucchiarini M., rAAV-mediated overexpression of TGF-beta stably restructures human osteoarthritic articular cartilage in situ, J Transl Med, 11, (2013)
  • [67] Vinardell T., Rolfe R.A., Buckley C.T., Meyer E.G., Ahearne M., Murphy P., Kelly D.J., Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells, Eur Cell Mater, 23, pp. 121-132, (2012)
  • [68] Wang Y., Simpson J.A., Wluka A.E., Teichtahl A.J., English D.R., Giles G.G., Graves S., Cicuttini F.M., Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study, Arthritis Res Ther, 11, 2, (2009)
  • [69] Weimer A., Madry H., Venkatesan J.K., Schmitt G., Frisch J., Wezel A., Jung J., Kohn D., Terwilliger E.F., Trippel S.B., Cucchiarini M., Benefits of rAAV-mediated IGF-I overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis, Mol Med, 18, 1, pp. 346-358, (2012)
  • [70] Werkmeister E., de Isla N., Marchal L., Stoltz J.F., Dumas D., Interest of second harmonic generation imaging for diagnosis in thick and opaque tissue, Biorheology, 45, 3-4, pp. 375-383, (2008)
12345678