New trends in articular cartilage repair

被引：12
作者：
Cucchiarini M. [1 ,2 ]
Henrionnet C. [2 ,3 ]
Mainard D. [2 ,3 ]
Pinzano A. [2 ,3 ]
Madry H. [1 ,2 ,4 ]
机构：
[1] Center of Experimental Orthopaedics, Saarland University Medical Center and Saarland University, Bldg 37, Kirrbergerstr. 1, Homburg
[2] Cartilage Net of the Greater Region, Homburg
[3] Ingénierie Moléculaire et Physiopathologie Articulaire, Unité Mixte de Recherches 7365 Centre National de la Recherche Scientifique, Université de Lorraine, Vandoeuvre Lès Nancy
[4] Department of Orthopaedic Surgery, Saarland University Medical Center and Saarland University, Homburg/Saar
来源：
Journal of Experimental Orthopaedics | / 2卷 / 1期
关键词：
Bioengineering; Cartilage repair; Infrapatellar fat pad; Non-invasive second harmonic generation imaging; Osteoarthritis; rAAV gene therapy; Stem cells;
D O I：
10.1186/s40634-015-0026-0
中图分类号：
学科分类号：
摘要：
Damage to the articular cartilage is an important, prevalent, and unsolved clinical issue for the orthopaedic surgeon. This review summarizes innovative basic research approaches that may improve the current understanding of cartilage repair processes and lead to novel therapeutic options. In this regard, new aspects of cartilage tissue engineering with a focus on the choice of the best-suited cell source are presented. The importance of non-destructive cartilage imaging is highlighted with the recent availability of adapted experimental tools such as Second Harmonic Generation (SHG) imaging. Novel insights into cartilage pathophysiology based on the involvement of the infrapatellar fat pad in osteoarthritis are also described. Also, recombinant adeno-associated viral vectors are discussed as clinically adapted, efficient tools for potential gene-based medicines in a variety of articular cartilage disorders. Taken as a whole, such advances in basic research in diverse fields of articular cartilage repair may lead to the development of improved therapies in the clinics for an improved, effective treatment of cartilage lesions in a close future. © 2015, Cucchiarini et al.; licensee Springer.
引用
收藏
页码：1 / 8
页数：7
相关论文
共 73 条
  • [1] Arai Y., Kubo T., Fushiki S., Mazda O., Nakai H., Iwaki Y., Imanishi J., Hirasawa Y., Gene delivery to human chondrocytes by an adeno associated virus vector, J Rheumatol, 27, 4, pp. 979-982, (2000)
  • [2] Benya P.D., Padilla S.R., Nimni M.E., Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture, Cell, 15, 4, pp. 1313-1321, (1978)
  • [3] Carpentier A.C., Frisch F., Labbe S.M., Gagnon R., de Wal J., Greentree S., Petry H., Twisk J., Brisson D., Gaudet D., Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients, J Clin Endocrinol Metab, 97, 5, pp. 1635-1644, (2012)
  • [4] Clockaerts S., Bastiaansen-Jenniskens Y.M., Runhaar J., Van Osch G.J., Van Offel J.F., Verhaar J.A., De Clerck L.S., Somville J., The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review, Osteoarthritis Cartilage, 18, 7, pp. 876-882, (2010)
  • [5] Cucchiarini M., Ekici M., Schetting S., Kohn D., Madry H., Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2, Tissue Eng Part A, 17, 15-16, pp. 1921-1933, (2011)
  • [6] Cucchiarini M., Madry H., Gene therapy for cartilage defects, J Gene Med, 7, 12, pp. 1495-1509, (2005)
  • [7] Cucchiarini M., Madry H., The potential of gene transfer for the treatment of osteoarthritis, Regen Med, 9, 1, pp. 5-8, (2013)
  • [8] Cucchiarini M., Madry H., Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo, Gene Ther, 21, 9, pp. 811-819, (2014)
  • [9] Cucchiarini M., Madry H., Guilak F., Saris D.B., Stoddart M.J., Koon Wong M., Roughley P., A vision on the future of articular cartilage repair, Eur Cell Mater, 27, pp. 12-16, (2014)
  • [10] Cucchiarini M., Madry H., Ma C., Thurn T., Zurakowski D., Menger M.D., Kohn D., Trippel S.B., Terwilliger E.F., Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2, Mol Ther, 12, 2, pp. 229-238, (2005)
12345678