CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target

被引：0
作者：
Mizuhiko Terasaki
Yasuo Sugita
Fumiko Arakawa
Yosuke Okada
Koichi Ohshima
Minoru Shigemori
机构：
[1] Kurume University School of Medicine,Department of Neurosurgery
[2] Kurume University School of Medicine,Department of Pathology
来源：
Brain Tumor Pathology | 2011年 / 28卷
关键词：
CXCL12; CXCR4; Glioblastoma; Primary central nervous system lymphoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chemokines are 8- to 12-kDa peptides that function as chemoattractant cytokines involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled, seven-span transmembrane receptors on the plasma membrane of target cells. Chemokine (C-X-C motif) ligand 12 (CXCL12), an alpha-chemokine that binds to G-protein-coupled chemokine (C-X-C motif) receptor 4 (CXCR4), plays an important and unique role in the regulation of stem/progenitor-cell trafficking. As CXCR4 is expressed on several cancer cells, these CXCR4-positive cancer cells may metastasize to organs that secrete/express CXCL12. Regarding brain tumors, recent data demonstrate that glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via the CXCL12/CXCR4 pathway. In addition, CXCL12/CXCR4 have recently been shown to be expressed in primary central nervous system (PCNS) lymphomas, and a role for chemokines in the pathogenesis of PCNS lymphomas was suggested. This review focuses on current knowledge regarding the biology of the CXCL12/CXCR4 pathway in the context of understanding their potential role in malignant gliomas and PCNS lymphoma development. The CXCL12/CXCR4 interaction as a therapeutic target for malignant brain tumors is also discussed.
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页码：89 / 97
页数：8
相关论文
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[1]  
Kucia M(2004)CXCR4-SDF1 signalling, locomotion, chemotaxis and adhesion J Mol Histol 35 233-245
[2]  
Jankowski K(2007)CXCL12(SDF1)/CXCR4 pathway in cancer Clin Cancer Res 16 2927-2931
[3]  
Reca R(2003)Role of the alpha-chemokine stromal cell-derived factor (SDF1) in the developing and mature central nervous system Glia 42 139-148
[4]  
Teicher BA(2010)Network in the development and progression of ovarian cancer: a potential novel pharmacological target J Oncol 61 4961-4965
[5]  
Fricker SP(2004)CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion Lab Invest 84 1666-1676
[6]  
Lazarini F(2006)Expression of chemokine CXCL12 and its receptor CXCR4 in human epithelial ovarian cancer: an independent prognostic factor for tumor progression Gynecol Oncol 103 226-233
[7]  
Tham TN(2006)Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer Cancer Res 66 2181-2187
[8]  
Casanova P(2009)SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation Development 136 1919-1928
[9]  
Barbieri F(2009)Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1 Cancer Res 69 7243-7251
[10]  
Bajetto A(2003)Expression of B-cell-attracting chemokine 1(CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma Blood 101 815-821
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