One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study

被引：0
作者：
A. M. Şenışık
Ç. İçhedef
A. Y. Kılçar
E. Uçar
K. Arı
D. Göksoy
Y. Parlak
Bedriye Elvan Sayıt Bilgin
S. Teksöz
机构：
[1] Istanbul Kemerburgaz University,Vocational School of Health Services/Radiotheraphy
[2] Ege University,Department of Nuclear Applications, Institute of Nuclear Sciences
[3] Celal Bayar University,Departmant of Nuclear Medicine
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2018年 / 316卷
关键词：
FDG; Imaging; Glycylglycine; PET; Radiopharmaceuticals;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [18F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [18F]FDG solution. The radiolabeled product ([18F]FDG-GlyGly) was obtained with 98.65 ± 0.35% yield without any purification step which makes this method more attractive for 18F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [18F]FDG tagged GlyGly in vivo.
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页码：457 / 463
页数：6
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