Evasion of the human innate immune system by dengue virus

被引：1
作者：
Sarah Pagni
Ana Fernandez-Sesma
机构：
[1] Mount Sinai School of Medicine,Department of Microbiology
[2] Mount Sinai School of Medicine,Global Health and Emerging Pathogens Institute (GHEPI)
来源：
Immunologic Research | 2012年 / 54卷
关键词：
Dengue virus; Innate immune response; Dengue hemorrhagic fever;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Dengue virus is a worldwide health problem, with billions of people at risk annually. Dengue virus causes a spectrum of diseases, namely dengue fever, dengue hemorrhagic fever and dengue shock syndrome with the latter two being linked to death. Understanding how dengue is able to evade the immune system and cause enhanced severity of disease is the main topics of interest in the Fernandez-Sesma laboratory at Mount Sinai School of Medicine. Using primary human immune cells, our group investigates the contribution of dengue virus-specific proteins to the evasion of innate immunity by this virus and the host factors that the virus interacts with in order to evade immune recognition and to establish infection in humans. Here, we review recent findings from our group as well as published data from other groups regarding immune modulation by dengue virus.
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页码：152 / 159
页数：7
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