Association of interleukin 4 VNTR polymorphism and HIV/AIDS in a north Indian seropositive patients

被引：0
作者：
Ranbiden Chandera Sobti
Nega Berhane
Salih Abdul Mahdi
Hitnder Takur
Ajay Wanch
机构：
[1] Panjab University,Department of Biotechnology
[2] Postgraduate Institute of Medical Education and Research,Department of Internal Medicine
[3] University of Gondar,Department of Biotechnology
来源：
Molecular Biology Reports | 2012年 / 39卷
关键词：
HIV/AIDS; -; VNTR; Disease progression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Despite different efforts made to intervene with the deadly nature of HIV/AIDS, all attempts remained unsuccessful due to complexity of the viral host interactions. The solution to HIV-1 pandemic is still to come, thus to assist the efforts being made to intervene with the deadly nature of the virus, different factors responsible for the disease burdens have to be looked into a systematic manner. As a result, the present study aimed to find out the association of IL-4 VNTR polymorphism with HIV-1 susceptibility and rate of disease progression. Three hundred cases and an equal number of sex and age matched controls were included for this study. The polymerase chain reaction assay was utilized to genotype IL-4 VNTR. The results of this study showed statistically significant variation among cases and controls in the distribution of the Rp2/Rp2 genotype (OR = 0.36, 95% CI = 0.18–0.69; P value = 0.0014) indicating, thereby, a possibility of reduced risk of HIV-1 susceptibility. Thus, Rp2/Rp2 genotype of the IL-4 might have a role to play in reducing risk of HIV-1 susceptibility among a north Indian population.
引用
收藏
页码：3251 / 3257
页数：6
相关论文
共 212 条
  • [11] Lemon RS(1999)HMGB1 as a late mediator of lethal systemic inflammation Immunology 96 1030-206
  • [12] Espinosa R(2000)Lack of infection in HIV-exposed individuals is associated with a strong CD8 cell noncytotoxic anti-HIV response Nat Med 6 200-210
  • [13] Larson RA(2000)Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection Nat Med l6 207-210
  • [14] Arai N(1999)Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies Nat Med 5 204-1490
  • [15] Rowley JD(1996)Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys J Infect Dis 173 1485-333
  • [16] Soriano A(1990)Dynamics of virus versus host interaction in children with human immune deficiency infection type 1 infection Annu Rev Immunol 8 303-435
  • [17] Lozano F(2005)Lymphokine control of in vivo immunoglobulin isotype selection BJU Intern 95 432-S120
  • [18] Oliva H(2002)Interleukin-4 gene intron-3 polymorphism is associated with transitional cell carcinoma of the urinary bladder Cell Suppl 109 S109-758
  • [19] Garcia F(2002)Transcription: tantalizing times for T cells Immunity 16 755-8891
  • [20] Nomdedéu M(1991)Further checkpoints in Th1 development Nucleic Acids Res 19 3763-196
12345678910