The role of exercise and PGC1α in inflammation and chronic disease

被引：0
作者：
Christoph Handschin
Bruce M. Spiegelman
机构：
[1] Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP),Dana
[2] University of Zurich,Farber Cancer Institute and Department of Cell Biology
[3] Harvard Medical School,undefined
来源：
Nature | 2008年 / 454卷
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D O I：
暂无
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学科分类号：
摘要：
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
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页码：463 / 469
页数：6
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