Effects of the C1473G Polymorphism in the Tryptophan Hydroxylase 2 Gene and the Length of Daylight on Behavior in Mice

被引：0

作者：

Khotskin N.V. ^{[1
]}

Bajenova E.Y. ^{[1
]}

Kulikova E.A. ^{[1
]}

Sorokin I.E. ^{[1
]}

Kulikov A.V. ^{[1
]}

机构：

[1] Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences (ICG SB RAS), Novosibirsk

来源：

Neuroscience and Behavioral Physiology | 2020年 / 50卷 / 2期

关键词：

behavior; daylight length; elevated plus maze; forced swimming; mice; open field; tryptophan hydroxylase 2;

D O I：

10.1007/s11055-019-00887-w

中图分类号：

学科分类号：

摘要：

Seasonal depressive disorder occurs in conditions of seasonal reductions in the duration of daylight and is a significant medical, social, and economic problem. The risk of seasonal depressive disorders is linked with impairments to the serotonin system of the brain. Tryptophan hydroxylase 2 (TPH2) is the key enzyme in serotonin synthesis in the brain. The C1473G polymorphism in the gene encoding TPH2 in mice leads to a twofold decrease in the activity of this enzyme in the mouse brain. The aim of the present work was to study the effects of the length of daylight on the behavior of mature males of the congenic strains B6-1473C and B6-1473G, which have high and low levels of TPH2 activity, respectively. Adult males of these strains were kept for one month in conditions of long (14 h) or short (4 h) daylight durations. Being kept in conditions of short daylight had no effect on mean day-round movement activity, food and water consumption, or anxiety in the open field and elevated plus maze tests in either mouse strain, but decreased mean sleep duration (p < 0.002) and active resistance in the forced swimming test (p < 0.01), changes being similar in both strains. Thus, the C1743G polymorphism had no effect on changes in behavior induced in mice by short daylight. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

引用

页码：192 / 198

页数：6

共 27 条

[1]

Bains R.S., Wells S., Sillito R.R., Armstrong J.D., Cater H.L., Banks G., Nolan P.M., Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools, Journal of Neuroscience Methods, 300, pp. 37-47, (2018)

[2]

Barkus C., Genetic mouse models of depression, Curr. Top. Behav. Neurosci., 14, pp. 55-78, (2013)

[3]

Bazhenova E.Y., Bazovkina D.V., Kulikova E.A., Et al., C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress, Neurosci. Lett., 640, pp. 105-110, (2017)

[4]

Bazovkina D.V., Lichman D.V., Kulikov A.V., The C1473G polymorphism in the Tryptophan hydroxylase-2 gene: involvement in ethanol-related behavior in mice, Neurosci. Lett., 589, pp. 79-82, (2015)

[5]

Bourin M., Animal models for screening anxiolytic-like drugs: a perspective, Dialogues Clin. Neurosci., 17, pp. 295-303, (2015)

[6]

Ennaceur A., Chazot P.L., Preclinical animal anxiety research - flaws and prejudices, Pharmacol. Res. Perspect., 4, (2016)

[7]

Fisher S.P., Godinho S.I., Pothecary C.A., Et al., Rapid assessment of sleep-wake behavior in mice, J. Biol. Rhythms, 27, pp. 48-58, (2012)

[8]

Kulikov A.V., Osipova D.V., Naumenko V.S., Popova N.K., Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains, Genes Brain Behav., 4, 8, pp. 482-485, (2005)

[9]

Kulikov A.V., Popova N.K., Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives?, Rev. Neurosci., 26, 6, pp. 679-690, (2015)

[10]

Kulikov V.A., Khotskin N.V., Nikitin S.V., Et al., Application of 3-D imaging sensor for tracking minipigs in the open field test, J. Neurosci. Meth., 235, pp. 219-225, (2014)

← 1 2 3 →