Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases

被引：88
作者：
Mossman B.T. [1 ]
Borm P.J. [2 ]
Castranova V. [3 ]
Costa D.L. [4 ]
Donaldson K. [5 ]
Kleeberger S.R. [6 ]
机构：
[1] Department of Pathology, University of Vermont, Burlington, VT 05405
[2] University of Heerlen, CEL, Heerlen 6400 AN
[3] National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, WV 26505
[4] Environmental Protection Agency, EPA/ORD, Research Triangle Park
[5] Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ
[6] National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
来源：
Particle and Fibre Toxicology | / 4卷 / 1期
关键词：
Heart Rate Variability; Idiopathic Pulmonary Fibrosis; Ultrafine Particle; Diesel Exhaust Particle; Intratracheal Instillation;
D O I：
10.1186/1743-8977-4-4
中图分类号：
学科分类号：
摘要：
Background: A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28, 2005, at the Environmental Protection Agency (EPA) Conference Center in Research Triangle Park, North Carolina. The meeting was the eighth in a series of transatlantic conferences first held in Penarth, Wales, at the Medical Research Council Pneumoconiosis Unit (1979), that have fostered long-standing collaborations between researchers in the fields of mineralogy, cell and molecular biology, pathology, toxicology, and environmental/occupational health. Results: The goal of this meeting, which was largely supported by a conference grant from the NHLBI, was to assemble a group of clinical and basic research scientists who presented and discussed new data on the mechanistic effects of inhaled particulates on the onset and development of morbidity and mortality in the lung and cardiovascular system. Another outcome of the meeting was the elucidation of a number of host susceptibility factors implicated in adverse health effects associated with inhaled pathogenic particulates. Conclusion: New models and data presented supported the paradigm that both genetic and environmental (and occupational) factors affect disease outcomes from inhaled particulates as well as cardiopulmonary responses. These future studies are encouraged to allow the design of appropriate strategies for prevention and treatment of particulate-associated morbidity and mortality, especially in susceptible populations. © 2007 Mossman et al; licensee BioMed Central Ltd.
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共 45 条
[1]  
Vineis P., Husgafvel-Pursiainen K., Air pollution and cancer: Biomarker studies in human populations, Carcinogenesis, 26, pp. 1846-1855, (2005)
[2]  
Riediker M., Cascio W.E., Griggs T.R., Herbst M.C., Bromberg P.A., Neas L., Williams R.W., Devlin R.B., Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men, Am J Respir Crit Care Med, 169, pp. 934-940, (2004)
[3]  
Peters A., von Klot S., Heier M., Trentinaglia I., Hormann A., Wichmann H.E., Lowel H., Exposure to traffic and the onset of myocardial infarction, N Engl J Med, 351, pp. 1721-1730, (2004)
[4]  
Schwartz J., Park S.K., O'Neill M.S., Vokonas P.S., Sparrow D., Weiss S., Kelsey K., Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: Gene-by-drug-by-environment interaction, Am J Respir Crit Care Med, 172, pp. 1529-1533, (2005)
[5]  
O'Neill M.S., Veves A., Zanobetti A., Sarnat J.A., Gold D.R., Economides P.A., Horton E.S., Schwartz J., Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function, Circulation, 111, pp. 2913-2920, (2005)
[6]  
Sun Q., Wang A., Jin X., Natanzon A., Duquaine D., Brook R.D., Aguinaldo J.G., Fayad Z.A., Fuster V., Lippmann M., Chen L.C., Rajagopalan S., Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model, Jama, 294, pp. 3003-3010, (2005)
[7]  
Nemmar A., Hoylaerts M.F., Hoet P.H., Dinsdale D., Smith T., Xu H., Vermylen J., Nemery B., Ultrafine particles affect experimental thrombosis in an in vivo hamster model, Am J Respir Crit Care Med, 166, pp. 998-1004, (2002)
[8]  
Whittaker A., BeruBe K., Jones T., Maynard R., Richards R., Killer smog of London, 50 years on: Particle properties and oxidative capacity, Sci Total Environ, pp. 334-335, (2004)
[9]  
BeruBe K.A., Whittaker A., Jones T.P., Moreno T., Merolla L., London's killer smog: How did they kill?, Proceedings of the Royal Microscopy Society, 40, pp. 171-183, (2005)
[10]  
BeruBe K., Balharry D., Jones T., Hayden P., Moreno T., Hayden P., Sexton K., Hicks M., Merolla L., Timblin C., Shukla A., Mossman B., Characterisation of airborne particulate matter and related mechanisms of toxicity: An experimental approach, Air Pollution and Health, 3, pp. 69-110, (2006)
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