Gastroparesis in the 2020s: New Treatments, New Paradigms

被引：20
作者：
Sharma A. [1 ]
Coles M. [2 ]
Parkman H.P. [3 ]
机构：
[1] Division of Gastroenterology & Hepatology, Medical College of Georgia, Digestive Health Center, Augusta University, 1120 15th St, AD-2226, Augusta, 30912, GA
[2] Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA
[3] Division of Gastroenterology & Hepatology, Lewis Katz School of Medicine, Temple University Hospital, Philadelphia, PA
来源：
Current Gastroenterology Reports | 2020年 / 22卷 / 5期
关键词：
Gastric emptying breath test; Gastric emptying scintigraphy; Gastroparesis; Neuromodulation; Pro-motility agents; Wireless motility capsule;
D O I：
10.1007/s11894-020-00761-7
中图分类号：
学科分类号：
摘要：
Purpose of Review: This review highlights recent work that will lead to near-term advances in the understanding and treatment of gastroparesis (Gp). Recent Findings: Major current advancements in the pathophysiology of Gp, include recognition of the SIP syncytium as the pacemaking unit rather than ICC alone and that Gp may be part of a pan-enteric autoimmune and/or autonomic disorder with macrophage imbalance. The development of newer techniques to assess gastric emptying (gastric emptying breath test and wireless motility capsule) and pyloric distensibility (EndoFLIP®) are allowing clinicians better characterization of their patients. In addition to pharmaceutical compounds in the pipeline, neuromodulation and endosurgical techniques, such as G-POEM, may help address refractory Gp. Summary: We expect that the 2020 decade will witness exciting developments. Treatments targeting gastrointestinal motility, immunological dysfunction, and inflammatory mediators will be evaluated. We anticipate future studies will be guided by biomarkers correlated with patient outcomes and therapeutic efficacy to establish new paradigms in the management of Gp. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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共 94 条
[1]  
Camilleri M., Parkman H.P., Shafi M.A., Et al., Clinical guideline: management of gastroparesis, Am J Gastroenterol, 108, pp. 18-37, (2013)
[2]  
Jung H.K., Choung R.S., Locke G.R., Et al., The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006, Gastroenterology, 136, pp. 1225-1233, (2009)
[3]  
Navas C.M., Patel N.K., Lacy B.E., Gastroparesis: medical and therapeutic advances, Dig Dis Sci, 62, pp. 2231-2240, (2017)
[4]  
Rey E., Choung R.S., Schleck C.D., Zinsmeister A.R., Talley N.J., Locke G.R., Prevalence of hidden gastroparesis in the community: the gastroparesis "iceberg, J Neurogastroenterol Motil, 18, pp. 34-42, (2012)
[5]  
Forouhi N.G., Wareham N.J., Epidemiology of diabetes, Medicine (Abingdon), 42, pp. 698-702, (2014)
[6]  
Wang Y.R., Fisher R.S., Parkman H.P., Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995-2004, Am J Gastroenterol, 103, pp. 313-322, (2008)
[7]  
Yu D., Ramsey F.V., Norton N.J., Et al., Mo1581 impaired quality of life in Gastroparesis: relationships to symptoms of gastroparesis, Gastroenterology, 150, (2016)
[8]  
Sanders K.M., Kito Y., Hwang S.J., Ward S.M., Regulation of gastrointestinal smooth muscle function by interstitial cells, Physiology, 31, pp. 316-326, (2016)
[9]  
Brini M., Carafoli E., Calcium pumps in health and disease, Physiol Rev, 89, pp. 1341-1378, (2009)
[10]  
Kelly J.P., DeVore A.D., Wu J., Et al., Rhythm control versus rate control in patients with atrial fibrillation and heart failure with preserved ejection fraction: insights from get with the guidelines-heart failure, J Am Heart Assoc, 8, (2019)
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