Zinc Supplementation Attenuates High Glucose-Induced Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelial Cells

被引：4
作者：
Xiuli Zhang
Jun Wang
Yi Fan
Lina Yang
Lining Wang
Jianfei Ma
机构：
[1] China Medical University,Department of Nephrology, the First Affiliated Hospital
[2] Benxi Railway Hospital,Department of Nephrology
来源：
Biological Trace Element Research | 2012年 / 150卷
关键词：
Rat peritoneal mesothelial cells; Zinc; Epithelial-to-mesenchymal transition; Mitogen-activated protein kinase; Smad; High glucose;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Zinc (Zn) plays an important role in preventing many types of epithelial-to-mesenchymal transition (EMT)-driven fibrosis in vivo. But its function in the EMT of the peritoneal mesothelial cells (PMCs) remains unknown. Here, we studied the Zn effect on the high glucose (HG)-induced EMT in the rat PMCs (RPMCs) and the underlying molecular mechanisms. We found that Zn supplementation significantly inhibited TGF-β1 and ROS production, and attenuated the HG-induced EMT in the RPMCs, likely through inhibition of MAPK, NF-κB, and TGF-β/Smad pathways.
引用
收藏
页码：229 / 235
页数：6
相关论文
共 172 条
[1]  
Yanez-Mo M(2003)Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells N Engl J Med 348 403-413
[2]  
Lara-Pezzi E(2005)Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum J Am Soc Nephrol 16 425-436
[3]  
Selgas R(2000)Biocompatibility of new peritoneal dialysis solutions: what can we hope to achieve? Perit Dial Int 20 S57-S67
[4]  
Ramirez-Huesca M(2001)High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells Kidney Int 59 463-470
[5]  
Dominguez-Jimenez C(1998)Effect of glucose concentration, osmolality, and sterilization process of peritoneal dialysis fluids on cytokine production by peripheral blood mononuclear cells and polymorphonuclear cell functions in vitro Am J Kidney Dis 31 273-282
[6]  
Jimenez-Heffernan JA(2008)The role of the TGF/Smad signaling pathway in peritoneal fibrosis induced by peritoneal dialysis solutions Nephron Exp Nephrol 109 e71-e78
[7]  
Margetts PJ(2009)HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium J Am Soc Nephrol 20 567-581
[8]  
Bonniaud P(2007)Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose Free Radic Biol Med 42 636-641
[9]  
Liu L(2006)Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane Kidney Int 69 2022-2028
[10]  
Hoff CM(1995)The function of metallothionein Neurochem Int 27 23-33
12345678910