A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines

被引：0
作者：
Amin Moghaddam
Wieslawa Olszewska
Belinda Wang
John S Tregoning
Rebecca Helson
Quentin J Sattentau
Peter J M Openshaw
机构：
[1] The Sir William Dunn School of Pathology,Department of Respiratory Medicine
[2] The University of Oxford,undefined
[3] Wright Fleming Institute,undefined
[4] Imperial College London,undefined
来源：
Nature Medicine | 2006年 / 12卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Heat, oxidation and exposure to aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors. Formaldehyde is widely used in making vaccines, but has been associated with atypical enhanced disease during subsequent infection with paramyxoviruses. We show that carbonyl groups on formaldehyde-treated vaccine antigens boost T helper type 2 (TH2) responses and enhance respiratory syncytial virus (RSV) disease in mice, an effect partially reversible by chemical reduction of carbonyl groups.
引用
收藏
页码：905 / 907
页数：2
相关论文
共 50 条
  • [41] Application of alginate microparticles incorporating formalin-inactivated Streptococcus parauberis for oral vaccination in olive flounder
    Kwang Il Kim
    Eun Young Min
    Tae-Ho Kim
    Hye Sung Choi
    Hyun-Ja Han
    [J]. Aquaculture International, 2021, 29 : 127 - 138
  • [42] Dynamic distribution of formalin-inactivated Edwardsiella tarda in flounder (Paralichthys olivaceus) post intraperitoneal vaccination
    Tang, Xiaoqian
    Gong, Jiaojiao
    Zeng, Chuili
    Sheng, Xiuzhen
    Xing, Jing
    Zhan, Wenbin
    [J]. FISH & SHELLFISH IMMUNOLOGY, 2019, 89 : 393 - 402
  • [43] FURTHER STUDIES ON THE EVALUATION OF IMMUNITY IN CHICKENS VACCINATED WITH FORMALIN-INACTIVATED NEWCASTLE DISEASE VIRUS VACCINE
    HOFSTAD, MS
    [J]. AMERICAN JOURNAL OF VETERINARY RESEARCH, 1956, 17 (65) : 738 - 741
  • [44] Stability of a formalin-inactivated Rift Valley fever vaccine: Evaluation of a vaccination campaign for cattle in Mozambique
    Lagerqvist, N.
    Moiane, B.
    Bucht, G.
    Fafetine, J.
    Paweska, J. T.
    Lundkvist, A.
    Falk, K. I.
    [J]. VACCINE, 2012, 30 (46) : 6534 - 6540
  • [45] IMMUNIZATION AGAINST RIFT VALLEY FEVER VIRUS - STUDIES ON IMMUNOGENICITY OF LYOPHILIZED FORMALIN-INACTIVATED VACCINE
    RANDALL, R
    HARRISON, VR
    BINN, LN
    [J]. JOURNAL OF IMMUNOLOGY, 1964, 93 (02) : 293 - &
  • [46] Application of alginate microparticles incorporating formalin-inactivated Streptococcus parauberis for oral vaccination in olive flounder
    Kim, Kwang Il
    Min, Eun Young
    Kim, Tae-Ho
    Choi, Hye Sung
    Han, Hyun-Ja
    [J]. AQUACULTURE INTERNATIONAL, 2021, 29 (01) : 127 - 138
  • [47] Efficacy of a formalin-inactivated vaccine against Lactococcus garvieae infection in golden pompano Trachinotus ovatus
    Lv, Jing
    Yang, Lindi
    Li, Yanping
    Yang, Shiping
    Cai, Shuanghu
    Jian, Jichang
    Huang, Yucong
    [J]. ISRAELI JOURNAL OF AQUACULTURE-BAMIDGEH, 2023, 75 (02):
  • [48] FORMALIN-INACTIVATED, ALUMINUM PHOSPHATE GEL-ADSORBED VACCINE OF BOVINE EPHEMERAL FEVER VIRUS
    INABA, Y
    KUROGI, H
    SATO, K
    GOTO, Y
    OMORI, T
    MATUMOTO, M
    [J]. ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG, 1973, 42 (01): : 42 - 53
  • [49] Antigenic characterization of a formalin-inactivated poliovirus vaccine derived from live-attenuated Sabin strains
    Tano, Yoshio
    Shimizu, Hiroyuki
    Martin, Javier
    Nishimura, Yorihiro
    Simizu, Bunsiti
    Miyamura, Tatsuo
    [J]. VACCINE, 2007, 25 (41) : 7041 - 7046
  • [50] Human metapneumovirus:: Enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challenged
    Yim, Kevin C.
    Cragin, Rose P.
    Boukhvalova, Marina S.
    Blanco, Jorge C. G.
    Hamlin, Marie-Eve
    Boivin, Guy
    Porter, David D.
    Prince, Gregory A.
    [J]. VACCINE, 2007, 25 (27) : 5034 - 5040
12345